Publications by authors named "M Mutschler"

Article Synopsis
  • This text discusses a unique medical case involving a patient with a specific genetic mutation (m.3243A>G) linked to MELAS, a condition that affects the brain and muscles.
  • The patient also experienced cardiomyopathy, a heart disease that can be serious and is associated with this condition.
  • The successful treatment involved performing a simultaneous heart and kidney transplant, marking an important milestone in managing this complex medical situation.
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Background: Along with the advent of newer bearings, hip resurfacing (HR) is gaining renewed interest as a bone sparing alternative to conventional total hip arthroplasty (THA) in young patients. However, the outcome of conversion of failed HR to THA (HRc) remains sparsely described. This study aimed to compare the outcomes and complication rates of HRc to those of primary (pTHA) and revision THA (rTHA) to find out to which group HRc is most comparable.

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Introduction: Circumscribed or pseudomalignant myositis ossificans (MO) is a rare and benign condition characterized by heterotopic bone formation in soft tissues. The clinical presentation of MO, imaging investigations, histological findings, and treatment strategies are unclear, especially in the pediatric population.

Materials And Methods: A literature search was conducted in PubMed, Scopus, and Google Scholar electronic databases to identify original articles and reviews in English or French of traumatic and non-traumatic MO.

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The objectives of this study were to ascertain the impact of endogenous production of trichome-exuded acylsugars on insects and insect transmitted virus by evaluating tomato lines and their hybrids bred for acylsugar production under field settings on whiteflies and the whitefly-transmitted tomato yellow leaf curl virus. Specifically, we utilized a diverse array of tomato lines and hybrids bred for changes in acylsugar amount or type, grown in three field trials under natural whitefly and virus pressure, to investigate whether the amount of accumulated acylsugars and or the chemical profile of the acylsugars were associated with greater resistance to whiteflies and reduced incidence of tomato yellow leaf curl virus. There was considerable variation in the abundance of whitefly eggs and nymphs and incidence of tomato yellow leaf curl virus across experiments and between entries.

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By conducting hierarchical clustering along a sliding window, we generated haplotypes across hundreds of re-sequenced genomes in a few hours. We leveraged our method to define cryptic introgressions underlying disease resistance in tomato (Solanum lycopersicum L.) and to discover resistant germplasm in the tomato seed bank.

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