Publications by authors named "M Mutoh"
Background: Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but discontinuation is difficult to maintain. The aim was to evaluate the real-world clinical results of anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) treatment for migraine with MOH without abrupt drug discontinuation and no hospitalization.
Methods: Data were collected before starting CGRP-mAb injections (baseline) and 1 month after each injection.
Evaluation of mild cognitive impairment in older patients with essential tremor.
Parkinsonism Relat Disord
February 2025
Introduction: Recent studies have reported that essential tremor (ET) presents with not only motor symptoms but also cognitive dysfunction. However, detailed pathological mechanisms remain unclear. Here, we evaluate the characteristics of cognitive changes in older patients.
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- Vitamin D is crucial for bone health and has been linked to COVID-19 severity, but little is known about its levels in pregnant women in Hokkaido, Japan.
- The study measured vitamin D2 and D3 levels in 206 pregnant women and analyzed their relationship with seasonal changes and sunshine exposure.
- Results showed that nearly all participants were vitamin D deficient, highlighting the need for interventions to improve vitamin D levels for the health of pregnant women and their babies.
Article Synopsis
- In familial adenomatous polyposis (FAP) patients, fundic gland polyps (FGPs) are thought to increase the risk of gastric neoplasms, and this study explored how the distribution of these polyps relates to cancer development.
- A review of 195 FAP patients showed that those with a wider distribution of FGPs (classified from P0 to P4) had a higher likelihood of developing gastric neoplasms, particularly in those who were Helicobacter pylori-negative.
- The study concluded that the pattern of FGP distribution is significantly linked to gastric neoplasm risk in FAP patients, with the most severe distribution (P4) indicating the highest risk.
Article Synopsis
- Familial adenomatous polyposis (FAP) is a hereditary condition leading to hundreds or thousands of colorectal polyps, which can progress to cancer if untreated; it’s caused by mutations in the APC gene.
- The report discusses two cases where women with FAP experienced an increase in fundic gland polyps after using proton pump inhibitors, which were then reduced upon switching medications.
- The study concludes that these types of medications can raise gastrin levels, leading to a rapid increase in polyps, and highlights the need for careful prescription of these drugs in FAP patients.