Bioactivated scaffolds promote angiogenesis and lymphangiogenesis for dermal regeneration in vivo.

Chronic wounds represent an unresolved medical challenge with significant impact for patients' quality of life and global healthcare. Diverse in origin, ischemic-hypoxic and inflammatory conditions play central roles as pathological features that impede proper tissue regeneration. In this study, we propose an innovative approach to address this challenge.

Spleen Involvement at Diagnosis of Multiple Myeloma: A Case Report and Literature Review.

Background: Multiple myeloma (MM) is more often characterized by clonal plasma cell proliferation restricted to the bone marrow. However, a small percentage of patients with MM develop extramedullary disease (EMD): this type of localization is found in 1.7%-4.

The effects of pharmacologic estradiol on anxiety-related behavior in adolescent and adult female mice.

Early pubertal onset during adolescence is consistently linked with increased risk of anxiety and depression in girls. Although estradiol tends to have anxiolytic effects on behavior in adulthood, whether estradiol's anxiolytic actions change pre- to post-adolescent development is not clear. Using a rodent model, the current study tested whether anxiety-like responses to estradiol differ before and after adolescence in female mice.

Primary Repair vs. Pulmonary Artery Banding in Complete Atrioventricular Canal Defects in the Modern Surgical Era.

Objectives: Impact of early age on outcomes for repair of complete atrioventricular canal defects (CAVC) remains poorly defined. We evaluated young infants with CAVC, comparing those who underwent primary repair vs. primary pulmonary artery banding (PAB) and results related to left atrioventricular valve (AVV) re-intervention and survival.