trying...
2064101MCID_676f0859814ac67a95013e30 39724286 Prasad M[author] M, Prasad[Full Author Name] OR prasad m[Author] m, prasad[Author] OR prasad m[Author] trying2...
trying...
3972428620241226
1460-24312024Dec26Journal of experimental botanyJ Exp BotMillets for a sustainable future.erae50710.1093/jxb/erae507Our current agricultural system faces a perfect storm-climate change, burgeoning population, and unpredictable outbreaks like COVID-19 disrupt food production, particularly for vulnerable populations in developing countries. A paradigm shift in agriculture practices is needed to tackle these issues. One solution is the diversification of crop production. While ~56% of the protein consumed from plants stems from three major cereal crops (rice, wheat and maize), underutilized crops such as millets, legumes and other cereals are highly neglected by farmers and the research community. Millets are one of the most ancient and versatile orphan crops with attributes like fast-growing, high-yielding, withstanding harsh environments, and rich in micronutrients such as iron and zinc, making them appealing to achieve agronomic sustainability. Here, we highlight the contribution of millet to agriculture and pay attention to the latest research on the genetic diversity of millet, genomic resources, and next-generation omics and their applications under various stress conditions. Additionally, integrative omics technologies could identify and develop millets with desirable phenotypes having high agronomic value and mitigating climate change. Here, we emphasize that biotechnological interventions, such as genome-wide association, genomic selection, genome editing, and artificial intelligence/machine learning, can improve and breed millets more effectively.© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Experimental Biology.GhatakArindamA0000-0003-4706-9841Molecular Systems Biology Lab (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.Vienna Metabolomics Center (VIME), University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.PieridesIroI0009-0004-6139-6229Molecular Systems Biology Lab (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.SinghRoshan KumarRKDepartment of Botany, Mahishadal Raj College, Purba Medinipur, Garh Kamalpur, West Bengal 721628, India.SrivastavaRakesh KRKCenter of Excellence in Genomics & Systems Biology, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Hyderabad, India.VarshneyRajeev KRKWA State Agricultural Biotechnology Centre, Centre for Crop & Food Innovation, Food Futures Institute, Murdoch University, Murdoch, 6150, Western Australia, Australia.PrasadManojMNational Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi, 110067, India.Department of Genetics, University of Delhi, South Campus, Benito-Juarez Road, New Delhi 110021, India.ChaturvediPalakP0000-0002-5856-0348Molecular Systems Biology Lab (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.WeckwerthWolframW0000-0002-9719-6358Molecular Systems Biology Lab (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.Vienna Metabolomics Center (VIME), University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.engJournal Article20241226
EnglandJ Exp Bot98829060022-0957IMbreedingclimate resilienceintegrated omicsmilletsmultiomicsstress tolerancesustainable development goals (SDGs)202498202412261816202412261816202412261557aheadofprint3972428610.1093/jxb/erae50779330953970065420241219
1878-75412112024Dec18Explore (New York, N.Y.)Explore (NY)Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study.10309910309910.1016/j.explore.2024.103099S1550-8307(24)00206-4Chronic lower back pain (CLBP) is a major condition that leads to disability and reduced quality of life (QoL). This randomised, double-blind, placebo-controlled clinical study evaluated the efficacy and safety of a novel Boswellia serrata and Curcuma longa combination (CL20192) for the treatment of CLBP.Participants with CLBP were randomised to receive either a 300 mg CL20192 capsule (n = 45) or placebo capsule (n = 45) once daily for 90 days. Efficacy was evaluated using the Descriptor Differential Scale and Oswestry Disability Index scores for pain, unpleasantness, and disability. Additionally, the 36-item short form questionnaire was used for QoL evaluation. Frequency of painkiller use, serum levels of inflammatory biomarkers (tumour necrosis factor-α, interleukin-6, and high-sensitivity C-reactive protein), and phytoconstituents (total boswellic acids and curcuminoids) were determined. Therapy satisfaction was assessed using the Physician and Patient Global Assessment Scales.All randomised participants completed the study. CL20192 supplementation significantly reduced Descriptor Differential Scale pain, unpleasantness, and Oswestry Disability Index scores compared with the placebo group (p < 0.001 for all parameters). Critical QoL scores greatly improved in the CL20192 group. Serum phytoconstituent levels were elevated in the CL20192-treated group. This group demonstrated a significant reduction in inflammatory biomarker levels (tumour necrosis factor-α, interleukin-6, and high-sensitivity C-reactive protein), confirming efficacy in abating CLBP compared with the placebo. Moreover, therapy satisfaction scores were significantly high in the CL20192-treated group, and intervention with CL20192 was well tolerated.Intervention with 300 mg CL20192 capsules, containing a novel combination of Boswellia serrata and Curcuma longa extracts, effectively alleviated pain, unpleasantness, and disability in patients with CLBP compared with the placebo. This outcome was consistent with a decrease in serum inflammatory markers and improved therapy assessment scores.Copyright © 2024 Elsevier Inc. All rights reserved.MajumdarAnuradhaADepartment of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai, India.PrasadMungara Anjaneya Venkata VaraMAVVVijaya Super Speciality Hospital, Raghava Cine Complex Road, SPSR Nellore, Andhra Pradesh, India.GandavarapuSatish ReddySRAster Prime Hospital, Maitrivanam, Satyam Theatre Road, Srinivasa Nagar, Ameerpet, Hyderabad, Telangana, India.ReddyKalakata Sudhir KumarKSKLandmark Hospital, Near JNTU Metro Station, Hyder Nagar, Main Road, Kukatpally, Hyderabad, Telangana, India.SurejaVarunVDepartment of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. Ltd., Ahmedabad, Gujarat, India. Electronic address: varun@sundyotanumandis.com.KheniDharmeshkumarDDepartment of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. Ltd., Ahmedabad, Gujarat, India.DubeyVishalVDepartment of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. Ltd., Ahmedabad, Gujarat, India.engJournal Article20241218
United StatesExplore (NY)1012331601550-8307IMBoswellia serrataCL20192Curcuma longaInflammationLower back painQuality of life202492020241262024129202412200232024122002320241219185aheadofprint3970065410.1016/j.explore.2024.103099S1550-8307(24)00206-43969184420241218
2212-42681512025Jan-FebJournal of oral biology and craniofacial researchJ Oral Biol Craniofac ResAn unusual surgical complication: Slipped molar lodged in vocal cords and its anesthetic management.222422-2410.1016/j.jobcr.2024.11.006Extraction of wisdom tooth is one of the most common surgical interventions, as it is more prone for impaction. Due to the pain and anxiety associated with the procedure, it is common to do this procedure under conscious sedation. However unexpected events do occur during the procedure and one such complication along with the prompt management is discussed here.This case report details an unusual occurrence of a third molar tooth slipping during dental extraction and becoming lodged at the base of the vocal cords. The patient, a 52-year-old man with a history of hypertension, underwent the procedure under conscious sedation. The case report highlights the importance of preparedness and multidisciplinary coordination in managing rare complications during dental procedures under conscious sedation. The accidental aspiration of a molar tooth into the airway required prompt and effective intervention, using dexmedetomidine for sedation, fibre-optic bronchoscopy for visualization, and a range of retrieval instruments. Using video-assisted laryngoscopy and fibre-optic laryngoscopy proved indispensable in locating and safely retrieving the foreign body without resorting to more invasive procedures.This case highlights the importance of anaesthesiologist's role in emergency management and comprehensive preparedness in dental practice.© 2024 The Authors.BegumAmeerunnishaADepartment of Anesthesiology and Pain Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 602105, India.RamRamsesh ManoharRMDepartment of Anesthesiology and Pain Medicine, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 602105, India.PrasadMonishaMCenter for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 602105, India.engJournal Article20241130
NetherlandsJ Oral Biol Craniofac Res1016191562212-4268The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.202473020241113202411232024121811332024121811322024121842820241130ppublish39691844PMC1165028110.1016/j.jobcr.2024.11.006S2212-4268(24)00173-8Webb W.A., McDaniel L., Jones L. Foreign bodies of the upper gastrointestinal tract: current management. South Med J. 1984;77:1083–1086.6484672Yadav R.K., Yadav H.K., Chandra A., Yadav S., Verma P., Shakya V.K. Accidental aspiration/ingestion of foreign bodies in dentistry: a clinical and legal perspective. Natl J Maxillofac Surg. 2015;6(2):144–151.PMC492222327390487da Silva E.J., de Almeida S.M., Bóscolo F.N. Accidental ingestion and aspiration of dental objects: a review of literature. Braz Dent J. 2012;23(6):591–595.0Lanigan D.T., Hey J.H., West R.A. Review of complications associated with local anesthetics, sedation, and general anesthesia in oral surgery. Anesth Prog. 1993;40(3):77–82.Haas D.A. An update on analgesics for the management of acute postoperative dental pain. J Can Dent Assoc. 2002;68(8):476–482.12323103Kamibayashi T., Maze M. Clinical uses of alpha2-adrenergic agonists. Anesthesiology. 2000;93(5):1345–1349.11046225Frerk C.M. Flexible fibreoptic laryngoscopy in anaesthetic practice. Br J Anaesth. 1990;64(4):448–451.Roberts J.R., Hedges J.R. sixth ed. Elsevier Health Sciences; 2013. Clinical Procedures in Emergency Medicine.American Society of Anesthesiologists Task Force on Moderate Procedural Sedation and Analgesia Practice guidelines for moderate procedural sedation and analgesia 2018. Anesthesiology. 2018;128(3):437–479.29334501Hidaka H., Suzuki T., Toyama H., Kurosawa S., Nomura K., Katori Y. Dislocated dental bridge covering the larynx: usefulness of tracheal tube guides under video-assisted laryngoscopy for induction of general anesthesia, thus avoiding tracheostomy. Head Face Med. 2014 Jun 11;10:23.PMC405948124919781Mottaghi K., Safari F., Nashibi M. Foreign body stuck between vocal cords. Tanaffos. 2016;15(4):246–248.PMC5410122284696823968499520241217
2227-903212232024Nov26Healthcare (Basel, Switzerland)Healthcare (Basel)Associations Between Retinal Vascular Occlusions and Dementia.237110.3390/healthcare12232371Retinal vascular occlusions, such as retinal vein occlusion (RVO) and retinal artery occlusion (RAO), are associated with cognitive impairment, including dementia. Our objective was to examine the odds of dementia among patients with retinal vascular occlusion.This cross-sectional study included 474 patients with retinal vascular occlusion and 948 patients without retinal vascular occlusion (comparison group). Patients in the comparison group were age- and sex-matched to those with vascular occlusion. Logistic regression was used to analyze the odds of all-cause dementia, vascular dementia, and Alzheimer's disease after adjusting for demographic, clinical, and ophthalmic covariates. Main outcome measures included the presence of all-cause dementia, vascular dementia, and Alzheimer's disease.Patients with RVO (n = 413) had increased odds for all-cause dementia (odds ratio (OR) = 2.32; 95% confidence interval (CI): 1.44-3.75; p < 0.001) and vascular dementia (OR = 3.29; 95% CI: 1.41-7.68; p = 0.006) relative to the comparison group. Patients with central RVO (n = 192) (OR = 2.32; 95% CI: 1.19-4.54; p = 0.014) or branch RVO (n = 221) (OR = 2.68; 95% CI: 1.30-5.50; p = 0.007) had increased odds for all-cause dementia relative to the comparison group. Patients with RAO (n = 61) did not have increased odds of all-cause dementia (OR = 1.01; 95% CI: 0.32-3.26; p = 0.983), vascular dementia (OR = 1.54; 95% CI: 0.22-10.81; p = 0.663), or Alzheimer's disease (OR = 0.32; 95% CI: 0.05-2.20; p = 0.244).A history of any RVO is associated with increased rates of all-cause dementia and vascular dementia independent of shared cardiovascular risk factors. These associations are not seen with a history of RAO, or between any subtype of vascular occlusions and Alzheimer's disease.PrasadMinaliM0000-0003-0596-1903Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.GoodmanDenizD0000-0002-7176-0694Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.GuttaSanhitS0009-0001-3640-0706Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.SheikhZahraZ0000-0002-8729-1802Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.CabralHoward JHJ0000-0002-1185-8331Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.ShunyakovaJennyJ0009-0003-9247-3381Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.SanjivNayanN0000-0001-6110-7387Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.CurleyCameronC0009-0005-2777-8482Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.YaralaRohun ReddyRR0009-0005-1242-6089Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.TsaiLynnaLDepartment of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.SiegelNicole HNH0000-0002-3523-8225Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.ChenXuejingX0000-0001-6827-0152Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.PoulakiVasilikiVDepartment of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.VA Boston Healthcare System, Boston, MA 02130, USA.AloscoMichael LMLBoston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.SteinThor DTD0000-0001-6954-4477VA Boston Healthcare System, Boston, MA 02130, USA.Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.VA Bedford Healthcare System, Bedford, MA 01730, USA.NessStevenS0000-0002-5843-9476Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.SubramanianManju LML0000-0002-0061-098XDepartment of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.Department of Ophthalmology, Boston Medical Center, Boston, MA 02118, USA.engJournal Article20241126
SwitzerlandHealthcare (Basel)1016665252227-9032Alzheimer’s diseaseretinal artery occlusionretinal vein occlusionvascular dementiaThe authors declare no conflicts of interest.202491920241110202411202024121711512024121711502024121711720241126epublish3968499510.3390/healthcare12232371healthcare12232371PMC11641452World Health Organization . Global Status Report on the Public Response to Dementia. World Health Organization; Geneva, Switzerland: 2021.Raz L., Knoefel J., Bhaskar K. The Neuropathology and Cerebrovascular Mechanisms of Dementia. J. Cereb. Blood Flow Metab. 2016;36:172–186. doi: 10.1038/jcbfm.2015.164.10.1038/jcbfm.2015.164PMC475855126174330Livingston G., Huntley J., Sommerlad A., Ames D., Ballard C., Banerjee S., Brayne C., Burns A., Cohen-Mansfield J., Cooper C., et al. Dementia Prevention, Intervention, and Care: 2020 Report of the Lancet Commission. Lancet. 2020;396:413–446. doi: 10.1016/S0140-6736(20)30367-6.10.1016/S0140-6736(20)30367-6PMC739208432738937Baumgart M., Snyder H.M., Carrillo M.C., Fazio S., Kim H., Johns H. Summary of the Evidence on Modifiable Risk Factors for Cognitive Decline and Dementia: A Population-Based Perspective. Alzheimers Dement. 2015;11:718–726. doi: 10.1016/j.jalz.2015.05.016.10.1016/j.jalz.2015.05.01626045020Bales T.R., Lopez M.J., Clark J. Embryology, Eye. StatPearls; Treasure Island, FL, USA: 2022.Singh R., Munakomi S. Embryology, Neural Tube. StatPearls; Treasure Island, FL, USA: 2022.31194425Marchesi N., Fahmideh F., Boschi F., Pascale A., Barbieri A. Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas. Cells. 2021;10:2394. doi: 10.3390/cells10092394.10.3390/cells10092394PMC846960534572041Ashok A., Singh N., Chaudhary S., Bellamkonda V., Kritikos A.E., Wise A.S., Rana N., McDonald D., Ayyagari R. Retinal Degeneration and Alzheimer’s Disease: An Evolving Link. Int. J. Mol. Sci. 2020;21:7290. doi: 10.3390/ijms21197290.10.3390/ijms21197290PMC758276633023198He S., Stankowska D.L., Ellis D.Z., Krishnamoorthy R.R., Yorio T. Targets of Neuroprotection in Glaucoma. J. Ocul. Pharmacol. Ther. 2018;34:85–106. doi: 10.1089/jop.2017.0041.10.1089/jop.2017.0041PMC596363928820649Liao C., Xu J., Chen Y., Ip N.Y. Retinal Dysfunction in Alzheimer’s Disease and Implications for Biomarkers. Biomolecules. 2021;11:1215. doi: 10.3390/biom11081215.10.3390/biom11081215PMC839495034439882Saccà S.C., Paluan F., Gandolfi S., Manni G., Cutolo C.A., Izzotti A. Common Aspects between Glaucoma and Brain Neurodegeneration. Mutat. Res. Rev. Mutat. Res. 2020;786:108323. doi: 10.1016/j.mrrev.2020.108323.10.1016/j.mrrev.2020.10832333339584Chan J.W., Chan N.C.Y., Sadun A.A. Glaucoma as Neurodegeneration in the Brain. Eye Brain. 2021;13:21–28. doi: 10.2147/EB.S293765.10.2147/EB.S293765PMC782208733500674Zhuang J., Madden D.J., Cunha P., Badea A., Davis S.W., Potter G.G., Lad E.M., Cousins S.W., Chen N.-K., Allen K., et al. Cerebral White Matter Connectivity, Cognition, and Age-Related Macular Degeneration. NeuroImage Clin. 2021;30:102594. doi: 10.1016/j.nicl.2021.102594.10.1016/j.nicl.2021.102594PMC793060933662707Wang Z., Lu Z., Li J., Pan C., Jia Z., Chen H., Ge X. Evaluation of Apparent Diffusion Coefficient Measurements of Brain Injury in Type 2 Diabetics with Retinopathy by Diffusion-Weighted MRI at 3.0 T. Neuroreport. 2017;28:69–74. doi: 10.1097/WNR.0000000000000703.10.1097/WNR.000000000000070327846040Lee C.S., Larson E.B., Gibbons L.E., Lee A.Y., McCurry S.M., Bowen J.D., McCormick W.C., Crane P.K. Associations between Recent and Established Ophthalmic Conditions and Risk of Alzheimer’s Disease. Alzheimer’s Dement. 2019;15:34–41. doi: 10.1016/j.jalz.2018.06.2856.10.1016/j.jalz.2018.06.2856PMC633351830098888Lee C.S., Lee M.L., Gibbons L.E., Yanagihara R.T., Blazes M., Kam J.P., Mccurry S.M., Bowen J.D., Mccormick W.C., Lee A.Y., et al. Associations between Retinal Artery/Vein Occlusions and Risk of Vascular Dementia. J. Alzheimers Dis. 2021;81:245–253. doi: 10.3233/JAD-201492.10.3233/JAD-201492PMC816861133749651Chan A.X., Bakhoum C.Y., Bangen K.J., Bakhoum M.F. Relationship between Retinal Vascular Occlusions and Cognitive Dementia in a Large Cross-Sectional Cohort. Am. J. Ophthalmol. 2021;226:201–205. doi: 10.1016/j.ajo.2021.01.026.10.1016/j.ajo.2021.01.026PMC922796033529587Nam G.E., Han K., Park S.H., Cho K.H., Song S.J. Retinal Vein Occlusion and the Risk of Dementia: A Nationwide Cohort Study. Am. J. Ophthalmol. 2021;221:181–189. doi: 10.1016/j.ajo.2020.07.050.10.1016/j.ajo.2020.07.05032777373Clausen A.R., Stokholm L., Blaabjerg M., Frederiksen K.H., Pedersen F.N., Grauslund J. Retinal Artery Occlusion Does Not Act as an Independent Marker of Upcoming Dementia: Results from a Danish 20-Year Cohort Study. Int. J. Retin. Vitr. 2023;9:50. doi: 10.1186/s40942-023-00488-3.10.1186/s40942-023-00488-3PMC1046674637644557Clausen A.R., Stokholm L., Frederiksen K.H., Möller S., Blaabjerg M., Pedersen F.N., Grauslund J. Retinal Vein Occlusion as an Age-dependent Marker of Incident Dementia in a Long-term Danish National Cohort. Acta Ophthalmol. 2023;102:455–461. doi: 10.1111/aos.15797.10.1111/aos.1579737874264Scott I.U., Campochiaro P.A., Newman N.J., Biousse V. Retinal Vascular Occlusions. Lancet. 2020;396:1927–1940. doi: 10.1016/S0140-6736(20)31559-2.10.1016/S0140-6736(20)31559-2PMC954663533308475Feldman B., Shah V.A., Tripathy K., Lee B., Bhagat N., Lim J.I., Karth P.A. Retinal Artery Occlusion. [(accessed on 19 October 2023)]. Available online: https://eyewiki.org/Retinal_Artery_Occlusion.Song P., Xu Y., Zha M., Zhang Y., Rudan I. Global Epidemiology of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis of Prevalence, Incidence, and Risk Factors. J. Glob. Health. 2019;9:10427. doi: 10.7189/jogh.09.010427.10.7189/jogh.09.010427PMC651350831131101Varma D.D., Cugati S., Lee A.W., Chen C.S. A Review of Central Retinal Artery Occlusion: Clinical Presentation and Management. Eye. 2013;27:688–697. doi: 10.1038/eye.2013.25.10.1038/eye.2013.25PMC368234823470793Lewallen S., Courtright P. Epidemiology in Practice: Case-Control Studies. Community Eye Health. 1998;11:57–58.PMC170607117492047Rehak M., Wiedemann P. Retinal Vein Thrombosis: Pathogenesis and Management. J. Thromb. Haemost. 2010;8:1886–1894. doi: 10.1111/j.1538-7836.2010.03909.x.10.1111/j.1538-7836.2010.03909.x20492457Guerreiro R., Bras J. The Age Factor in Alzheimer’s Disease. Genome Med. 2015;7:106. doi: 10.1186/s13073-015-0232-5.10.1186/s13073-015-0232-5PMC461723826482651Gao S., Hendrie H.C., Hall K.S., Hui S. The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease: A Meta-Analysis. Arch. Gen. Psychiatry. 1998;55:809–815. doi: 10.1001/archpsyc.55.9.809.10.1001/archpsyc.55.9.8099736007Appiah A.P., Trempe C.L. Differences in Contributory Factors among Hemicentral, Central, and Branch Retinal Vein Occlusions. Ophthalmology. 1989;96:364–366. doi: 10.1016/S0161-6420(89)32884-3.10.1016/S0161-6420(89)32884-32710528Goodman R.A., Lochner K.A., Thambisetty M., Wingo T.S., Posner S.F., Ling S.M. Prevalence of Dementia Subtypes in United States Medicare Fee-for-service Beneficiaries, 2011–2013. Alzheimer’s Dement. 2017;13:28–37. doi: 10.1016/j.jalz.2016.04.002.10.1016/j.jalz.2016.04.002PMC510468627172148Lamba P.A., Bhalla J.S., Mullick D.N. Ocular Manifestations of Tubercular Meningitis: A Clinico-Biochemical Study. J. Pediatr. Ophthalmol. Strabismus. 1986;23:123–125. doi: 10.3928/0191-3913-19860501-06.10.3928/0191-3913-19860501-063723294Hirai T., Ando Y., Yamura M., Kitajima M., Hayashida Y., Korogi Y., Yamashita T., Yamashita Y. Transthyretin-Related Familial Amyloid Polyneuropathy: Evaluation of CSF Enhancement on Serial T1-Weighted and Fluid-Attenuated Inversion Recovery Images Following Intravenous Contrast Administration. AJNR Am. J. Neuroradiol. 2005;26:2043–2048.PMC814882116155157Yen M.Y., Liu J.H. Malignant Lymphoma Involving the Optic Nerve Head and the Retina. Ann. Ophthalmol. 1985;17:697–700.4083658Sen H.N., Bodaghi B., Hoang P.L., Nussenblatt R. Primary Intraocular Lymphoma: Diagnosis and Differential Diagnosis. Ocul. Immunol. Inflamm. 2009;17:133–141. doi: 10.1080/09273940903108544.10.1080/09273940903108544PMC292417119585354Hong J.T., Chae J.B., Lee J.Y., Kim J.-G., Yoon Y.H. Ocular Involvement in Patients with Primary CNS Lymphoma. J. Neuro-Oncol. 2011;102:139–145. doi: 10.1007/s11060-010-0303-9.10.1007/s11060-010-0303-920658258Logan R., Davey P., De Souza N., Baird D., Guthrie B., Bell S. Assessing the Accuracy of ICD-10 Coding for Measuring Rates of and Mortality from Acute Kidney Injury and the Impact of Electronic Alerts: An Observational Cohort Study. Clin. Kidney J. 2020;13:1083–1090. doi: 10.1093/ckj/sfz117.10.1093/ckj/sfz117PMC776953333391753O’Malley K.J., Cook K.F., Price M.D., Wildes K.R., Hurdle J.F., Ashton C.M. Measuring Diagnoses: ICD Code Accuracy. Health Serv. Res. 2005;40:1620–1639. doi: 10.1111/j.1475-6773.2005.00444.x.10.1111/j.1475-6773.2005.00444.xPMC136121616178999Shi H., Koronyo Y., Rentsendorj A., Fuchs D.-T., Sheyn J., Black K.L., Mirzaei N., Koronyo-Hamaoui M. Retinal Vasculopathy in Alzheimer’s Disease. Front. Neurosci. 2021;15:731614. doi: 10.3389/fnins.2021.731614.10.3389/fnins.2021.731614PMC849324334630020Avunduk A.M., Dinç H., Kapicioǧlu Z., Uǧurlu Ş., Dayanir V., Korkmaz E. Arterial Blood Flow Characteristics in Central Retinal Vein Occlusion and Effects of Panretinal Photocoagulation Treatment: An Investigation by Colour Doppler Imaging. Br. J. Ophthalmol. 1999;83:50–53. doi: 10.1136/bjo.83.1.50.10.1136/bjo.83.1.50PMC172278510209435Mei X., Qiu C., Zhou Q., Chen Z., Chen Y., Xu Z., Zou C. Changes in Retinal Multilayer Thickness and Vascular Network of Patients with Alzheimer’s Disease. Biomed. Eng. Online. 2021;20:97. doi: 10.1186/s12938-021-00931-2.10.1186/s12938-021-00931-2PMC848905834602087Golzan S., Goozee K., Georgevsky D., Avolio A., Chatterjee P., Shen K., Gupta V., Chung R., Savage G., Orr C.F., et al. Retinal Vascular and Structural Changes Are Associated with Amyloid Burden in the Elderly: Ophthalmic Biomarkers of Preclinical Alzheimer’s Disease. Alzheimers Res. Ther. 2017;9:13. doi: 10.1186/s13195-017-0239-9.10.1186/s13195-017-0239-9PMC533579928253913Wang X., Zhao Q., Tao R., Lu H., Xiao Z., Zheng L., Ding D., Ding S., Ma Y., Lu Z., et al. Decreased Retinal Vascular Density in Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI): An Optical Coherence Tomography Angiography (OCTA) Study. Front. Aging Neurosci. 2021;12:572484. doi: 10.3389/fnagi.2020.572484.10.3389/fnagi.2020.572484PMC784350833519415Yeh T.-C., Kuo C.-T., Chou Y.-B. Retinal Microvascular Changes in Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review, Meta-Analysis, and Meta-Regression. Front. Aging Neurosci. 2022;14:860759. doi: 10.3389/fnagi.2022.860759.10.3389/fnagi.2022.860759PMC909623435572135Costanzo E., Parravano M., Gilardi M., Cavalleri M., Sacconi R., Aragona E., Varano M., Bandello F., Querques G. Microvascular Retinal and Choroidal Changes in Retinal Vein Occlusion Analyzed by Two Different Optical Coherence Tomography Angiography Devices. Ophthalmologica. 2019;242:8–15. doi: 10.1159/000496195.10.1159/00049619530721901Brar M., Sharma M., Grewal S.P.S., Grewal D.S. Quantification of Retinal Microvasculature and Neurodegeneration Changes in Branch Retinal Vein Occlusion after Resolution of Cystoid Macular Edema on Optical Coherence Tomography Angiography. Indian J. Ophthalmol. 2019;67:1864–1869. doi: 10.4103/ijo.IJO_1554_18.10.4103/ijo.IJO_1554_18PMC683659131638051Yoon S.P., Grewal D.S., Thompson A.C., Polascik B.W., Dunn C., Burke J.R., Fekrat S. Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants. Ophthalmol. Retin. 2019;3:489–499. doi: 10.1016/j.oret.2019.02.002.10.1016/j.oret.2019.02.002PMC658656031174670Cheung C.Y.L., Ong Y.T., Ikram M.K., Ong S.Y., Li X., Hilal S., Catindig J.A.S., Venketasubramanian N., Yap P., Seow D., et al. Microvascular Network Alterations in the Retina of Patients with Alzheimer’s Disease. Alzheimers Dement. 2014;10:135–142. doi: 10.1016/j.jalz.2013.06.009.10.1016/j.jalz.2013.06.00924439169Youm D.J., Ha M.M., Chang Y., Song S.J. Retinal Vessel Caliber and Risk Factors for Branch Retinal Vein Occlusion. Curr. Eye Res. 2012;37:334–338. doi: 10.3109/02713683.2011.629070.10.3109/02713683.2011.62907022324736Ikram M.K., De Jong F.J., Van Dijk E.J., Prins N.D., Hofman A., Breteler M.M.B., De Jong P.T.V.M. Retinal Vessel Diameters and Cerebral Small Vessel Disease: The Rotterdam Scan Study. Brain. 2006;129:182–188. doi: 10.1093/brain/awh688.10.1093/brain/awh68816317022Cho K.H., Kim C.K., Oh K., Oh S.-W., Park K.H., Park S.J. Retinal Vein Occlusion as the Surrogate Marker for Premature Brain Aging in Young Patients. Investig. Opthalmol. Vis. Sci. 2017;58:BIO82–BIO87. doi: 10.1167/iovs.17-21413.10.1167/iovs.17-2141328525562Dolan H., Crain B., Troncoso J., Resnick S.M., Zonderman A.B., Obrien R.J. Atherosclerosis, Dementia, and Alzheimer Disease in the Baltimore Longitudinal Study of Aging Cohort. Ann. Neurol. 2010;68:231–240. doi: 10.1002/ana.22055.10.1002/ana.22055PMC303077220695015Kwa VI H., Van der Sande J.J., Stam J., Tijmes N., Vrooland J.L. Retinal Arterial Changes Correlate with Cerebral Small-Vessel Disease. Neurology. 2002;59:1536–1540. doi: 10.1212/01.WNL.0000033093.16450.5C.10.1212/01.WNL.0000033093.16450.5C12451193Kim H.W., Hong J., Jeon J.C. Cerebral Small Vessel Disease and Alzheimer’s Disease: A Review. Front. Neurol. 2020;11:927. doi: 10.3389/fneur.2020.00927.10.3389/fneur.2020.00927PMC747739232982937Park S.J., Ahn S., Woo S.J., Park K.H. Extent of Exacerbation of Chronic Health Conditions by Visual Impairment in Terms of Health-Related Quality of Life. JAMA Ophthalmol. 2015;133:1267–1275. doi: 10.1001/jamaophthalmol.2015.3055.10.1001/jamaophthalmol.2015.305526379209Huang A.R., Roth D.L., Cidav T., Chung S.E., Amjad H., Thorpe R.J., Boyd C.M., Cudjoe T.K.M. Social Isolation and 9-Year Dementia Risk in Community-Dwelling Medicare Beneficiaries in the United States. J. Am. Geriatr. Soc. 2023;71:765–773. doi: 10.1111/jgs.18140.10.1111/jgs.18140PMC1002333136628523Poblador-Plou B., Calderón-Larrañaga A., Marta-Moreno J., Hancco-Saavedra J., Sicras-Mainar A., Soljak M., Prados-Torres A. Comorbidity of Dementia: A Cross-Sectional Study of Primary Care Older Patients. BMC Psychiatry. 2014;14:84. doi: 10.1186/1471-244X-14-84.10.1186/1471-244X-14-84PMC399452624645776Cha H., Farina M.P., Hayward M.D. Socioeconomic Status across the Life Course and Dementia-Status Life Expectancy among Older Americans. SSM-Popul. Health. 2021;15:100921. doi: 10.1016/j.ssmph.2021.100921.10.1016/j.ssmph.2021.100921PMC845288134584932Pase M.P., Rowsthorn E., Cavuoto M.G., Lavale A., Yassi N., Maruff P., Buckley R.F., Lim Y.Y. Association of Neighborhood-Level Socioeconomic Measures With Cognition and Dementia Risk in Australian Adults. JAMA Netw. Open. 2022;5:e224071. doi: 10.1001/jamanetworkopen.2022.4071.10.1001/jamanetworkopen.2022.4071PMC895697235333361Berkowitz S.T., Groth S.L., Gangaputra S., Patel S. Racial/Ethnic Disparities in Ophthalmology Clinical Trials Resulting in US Food and Drug Administration Drug Approvals From 2000 to 2020. JAMA Ophthalmol. 2021;139:629–637. doi: 10.1001/jamaophthalmol.2021.0857.10.1001/jamaophthalmol.2021.0857PMC806313033885724Sanjiv N., Osathanugrah P., Harrell M., Siegel N.H., Ness S., Chen X., Cabral H., Subramanian M.L. Race and Ethnic Representation among Clinical Trials for Diabetic Retinopathy and Diabetic Macular Edema within the United States: A Review. J. Natl. Med. Assoc. 2022;114:123–140. doi: 10.1016/j.jnma.2021.12.016.10.1016/j.jnma.2021.12.01635078668Shaw A.R., Perales-Puchalt J., Johnson E., Espinoza-Kissell P., Acosta-Rullan M., Frederick S., Lewis A., Chang H., Mahnken J., Vidoni E.D. Representation of Racial and Ethnic Minority Populations in Dementia Prevention Trials: A Systematic Review. J. Prev. Alzheimers Dis. 2021;9:113–118. doi: 10.14283/jpad.2021.49.10.14283/jpad.2021.49PMC880432735098981Reardon S. Alzheimer’s Drug Trials Plagued by Lack of Racial Diversity. Nature. 2023;620:256–257. doi: 10.1038/d41586-023-02464-1.10.1038/d41586-023-02464-1375328573967612220241215
1545-50172024Dec15Pediatric blood & cancerPediatr Blood CancerOutcomes Based on Histological Tumor Necrosis and Predictive Clinical and Laboratory Parameters for Necrosis in Children With Osteosarcoma Treated on a Non-High Dose Methotrexate-Based Chemotherapy Backbone.e31471e3147110.1002/pbc.31471Histopathological response to neoadjuvant chemotherapy (NACT) measured as tumor necrosis (TN) has been reported to be prognostic post-high-dose methotrexate (HDMTX)-based chemotherapy. We studied this on a non-HDMTX chemotherapy backbone.Children ≤15 years, with osteosarcoma treated on OGS-2012 protocol and surgery post NACT from January 2013 to December 2020 were retrospectively analyzed. TN was expressed as percentage. Outcomes based on different TN cutoffs (used in a dichotomized manner dividing the cohort into two groups of less than/greater than the particular cutoff) and clinical-laboratory parameters predictive of TN were studied.Analysis was done in 258 patients. Amputation was performed in 20.1%. Median TN was 94%. At a median follow-up of 38 months (range: 34-45 months), 3-year event free survival (EFS) and overall survival (OS) of the whole cohort were 56.1% (SE: 3.3%) and 87.8% (SE: 2.4%). For entire cohort, TN-70% (29.3% vs. 60.7%), 90% (38.7% vs. 69.0%), 100% (50.8% vs. 84.1%), were prognostic for EFS (p = 0.0001), while TN-90% (80.3% vs. 92.9%, p = 0.006) and 100% (85.5% vs. 97.7%, p = 0.023) were prognostic for OS. For localized disease, TN-70% (35.4% vs. 66.4%), 90% (41.6% vs. 77.0%), 100% (54.8% vs. 96.2%) were prognostic for EFS (p = 0.0001) and OS (p = 0.0001). For metastatic disease, TN-70% was prognostic for EFS (16.6% vs. 50.1%, p = 0.0047). Receiver-operator curve derived cutoff of 85.5% TN for EFS, 83.5% TN for OS prognosticated whole and localized cohorts the best. For metastatic cohort, 84.5% TN best prognosticated EFS. Among clinical-laboratory parameters, male gender (OR: 1.9, p = 0.01) and amputation (OR: 2.1, p = 0.014) had a higher risk of less than 90% TN.Tumor necrosis at 90% cutoff in localized disease is prognostic of survival even on a non-HDMTX-based backbone, but exploring other cutoffs for survival predictive and prognostic value could guide future treatment modification strategies and resource allocation in LMICs. Amputation, male gender predicts poor histological necrosis.© 2024 Wiley Periodicals LLC.ParambilBadira CheriyalinkalBC0000-0001-6459-2058Division of Pediatric Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.KhemaniPoonamPDivision of Pediatric Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.PuriAjayA0000-0002-4323-753XDepartment of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.GuliaAshishA0000-0002-5133-7442Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.PrasadMayaM0000-0003-0127-7987Division of Pediatric Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.GollamudiVenkata Ram MohanVRMDivision of Pediatric Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.RamadwarMuktaMDepartment of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.RekhiBharatBDepartment of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.PanjwaniPoonamPDepartment of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.NayakPrakashPDepartment of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.PruthiManishMDepartment of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.QureshiSajidS0000-0002-6770-5887Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.PurandareNilenduNDepartment of Nuclear Medicine, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.JanuAmitADepartment of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.PawarAkashAClinical Research Secretariat, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.AdhavKomalKDivision of Pediatric Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.ChinnaswamyGirishGDivision of Pediatric Oncology, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.engJournal Article20241215
United StatesPediatr Blood Cancer1011866241545-5009IMnon‐HDMTXosteosarcomaoutcomestumor necrosis202410172024262024111520241216113020241216113020241215235aheadofprint3967612210.1002/pbc.31471ReferencesJ. Whelan, A. McTiernan, N. Cooper, et al., “Incidence and Survival of Malignant Bone Sarcomas in England 1979–2007,” International Journal of Cancer 131, no. 4 (2012): E508–E517, https://doi.org/10.1002/ijc.26426.N. C. Daw, M. D. Neel, B. N. Rao, et al., “Frontline Treatment of Localized Osteosarcoma without Methotrexate: Results of the St. Jude Children's Research Hospital OS99 Trial,” Cancer 117, no. 12 (2011): 2770–2778, https://doi.org/10.1002/cncr.25715.J. S. Whelan, S. S. Bielack, N. Marina, et al., “EURAMOS‐1, an International Randomised Study for Osteosarcoma: Results From Pre‐Randomisation Treatment,” Annals of Oncology 26, no. 2 (2015): 407–414, https://doi.org/10.1093/annonc/mdu526.J. Bajpai, A. Chandrasekharan, V. Talreja, et al., “Outcomes in Non‐Metastatic Treatment Naive Extremity Osteosarcoma Patients Treated with a Novel Non‐High Dose Methotrexate‐Based, Dose‐Dense Combination Chemotherapy Regimen ‘OGS‐12’,” European Journal of Cancer 85 (2017): 49–58, https://doi.org/10.1016/j.ejca.2017.08.013.P. Verma, S. Jain, G. Kapoor, R. Tripathi, P. Sharma, and D. C. Doval, “IAP Chemotherapy Regimen is a Viable and Cost‐Effective Option in Children and Adolescents With Osteosarcoma: A Comparative Analysis With MAP Regimen on Toxicity and Survival,” Journal of Pediatric Hematology/Oncology 43, no. 4 (2021): e466–e471, https://doi.org/10.1097/MPH.0000000000001946.M. W. Bishop, Y. C. Chang, M. D. Krailo, et al., “Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG‐782 and INT0133—A Report From the Children's Oncology Group Bone Tumor Committee,” Pediatric Blood & Cancer 63, no. 10 (2016): 1737–1743, https://doi.org/10.1002/pbc.26034.N. Wadhwa, “Osteosarcoma: Diagnostic Dilemmas in Histopathology and Prognostic Factors,” Indian J Orthop 48, no. 3 (2014): 247–254, https://doi.org/10.4103/0019‐5413.132497.S. S. Bielack, B. Kempf‐Bielack, G. Delling, et al., “Prognostic Factors in High‐Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols,” Journal of Clinical Oncology 20, no. 3 (2002): 776–790, https://doi.org/10.1200/JCO.2002.20.3.776.J. K. Anninga, H. Gelderblom, M. Fiocco, et al., “Chemotherapeutic Adjuvant Treatment for Osteosarcoma: Where do We Stand?,” European Journal of Cancer (Oxford, England: 1990) 47, no. 16 (2011): 2431–2445, https://doi.org/10.1016/j.ejca.2011.05.030.N. M. Marina, S. Smeland, S. S. Bielack, et al., “Comparison of MAPIE Versus MAP in Patients With a Poor Response to Preoperative Chemotherapy for Newly Diagnosed High‐Grade Osteosarcoma (EURAMOS‐1): An Open‐Label, International, Randomised Controlled Trial,” Lancet Oncology 17, no. 10 (2016): 1396–1408, https://doi.org/10.1016/S1470‐2045(16)30214‐5.X. Li, A. O. Ashana, V. M. Moretti, and R. D. Lackman, “The Relation of Tumour Necrosis and Survival in Patients with Osteosarcoma,” International Orthopaedics 35, no. 12 (2011): 1847–1853, https://doi.org/10.1007/s00264‐011‐1209‐7.M. T. Harting, K. P. Lally, R. J. Andrassy, et al., “Age as a Prognostic Factor for Patients with Osteosarcoma: An Analysis of 438 Patients,” Journal of Cancer Research and Clinical Oncology 136, no. 4 (2010): 561–570, https://doi.org/10.1007/s00432‐009‐0690‐5.P. Picci, G. Bacci, M. Campanacci, et al., “Histologic Evaluation of Necrosis in Osteosarcoma Induced by Chemotherapy Regional Mapping of Viable and Nonviable Tumor,” Cancer 56, no. 7 (1985): 1515–1521, https://doi.org/10.1002/1097‐0142(19851001)56:7<1515::AID‐CNCR2820560707>3.0.CO;2‐6.G. Bacci, A. Briccoli, S. Ferrari, et al., “Neoadjuvant Chemotherapy for Osteosarcoma of the Extremity: Long‐Term Results of the Rizzoli's 4th Protocol,” European Journal of Cancer (Oxford, England: 1990) 37, no. 16 (2001): 2030–2039, https://doi.org/10.1016/s0959‐8049(01)00229‐5.I. J. Lewis, M. A. Nooij, J. Whelan, et al., “Improvement in Histologic Response but Not Survival in Osteosarcoma Patients Treated With Intensified Chemotherapy: A Randomized Phase III Trial of the European Osteosarcoma Intergroup,” JNCI: Journal of the National Cancer Institute 99, no. 2 (2007): 112–128, https://doi.org/10.1093/jnci/djk015.G. Bacci, M. Mercuri, A. Longhi, et al., “Grade of Chemotherapy‐Induced Necrosis as a Predictor of Local and Systemic Control in 881 Patients With Non‐Metastatic Osteosarcoma of the Extremities Treated With Neoadjuvant Chemotherapy in a Single Institution,” European Journal of Cancer (Oxford, England: 1990) 41, no. 14 (2005): 2079–2085, https://doi.org/10.1016/j.ejca.2005.03.036.S. Ferrari, F. Bertoni, M. Mercuri, et al., “Predictive Factors of Disease‐Free Survival for Non‐Metastatic Osteosarcoma of the Extremity: An Analysis of 300 Patients Treated at the Rizzoli Institute,” Annals of Oncology 12, no. 8 (2001): 1145–1150, https://doi.org/10.1023/A:1011636912674.G. Bacci, S. Ferrari, A. Longhi, et al., “Pattern of Relapse in Patients With Osteosarcoma of the Extremities Treated With Neoadjuvant Chemotherapy,” European Journal of Cancer (Oxford, England: 1990) 37, no. 1 (2001): 32–38, https://doi.org/10.1016/s0959‐8049(00)00361‐0.trying2...
Publications by M Muni Prasad | LitMetric
Browse Categories

Publications by authors named "M Muni Prasad"

  • Page 1 of 1
Millets for a sustainable future.
Arindam Ghatak Iro Pierides Roshan Kumar Singh Rakesh K Srivastava Rajeev K Varshney Manoj Prasad

J Exp Bot

December 2024

Our current agricultural system faces a perfect storm-climate change, burgeoning population, and unpredictable outbreaks like COVID-19 disrupt food production, particularly for vulnerable populations in developing countries. A paradigm shift in agriculture practices is needed to tackle these issues. One solution is the diversification of crop production.

View Article and Find Full Text PDF
Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study.
Anuradha Majumdar Mungara Anjaneya Venkata Vara Prasad Satish Reddy Gandavarapu Kalakata Sudhir Kumar Reddy Varun Sureja

Explore (NY)

December 2024

Background And Aim: Chronic lower back pain (CLBP) is a major condition that leads to disability and reduced quality of life (QoL). This randomised, double-blind, placebo-controlled clinical study evaluated the efficacy and safety of a novel Boswellia serrata and Curcuma longa combination (CL20192) for the treatment of CLBP.

Material And Methods: Participants with CLBP were randomised to receive either a 300 mg CL20192 capsule (n = 45) or placebo capsule (n = 45) once daily for 90 days.

View Article and Find Full Text PDF
An unusual surgical complication: Slipped molar lodged in vocal cords and its anesthetic management.
Ameerunnisha Begum Ramsesh Manohar Ram Monisha Prasad

J Oral Biol Craniofac Res

November 2024

Background: Extraction of wisdom tooth is one of the most common surgical interventions, as it is more prone for impaction. Due to the pain and anxiety associated with the procedure, it is common to do this procedure under conscious sedation. However unexpected events do occur during the procedure and one such complication along with the prompt management is discussed here.

View Article and Find Full Text PDF
Associations Between Retinal Vascular Occlusions and Dementia.
Minali Prasad Deniz Goodman Sanhit Gutta Zahra Sheikh Howard J Cabral

Healthcare (Basel)

November 2024

Background/objectives: Retinal vascular occlusions, such as retinal vein occlusion (RVO) and retinal artery occlusion (RAO), are associated with cognitive impairment, including dementia. Our objective was to examine the odds of dementia among patients with retinal vascular occlusion.

Methods: This cross-sectional study included 474 patients with retinal vascular occlusion and 948 patients without retinal vascular occlusion (comparison group).

View Article and Find Full Text PDF
Outcomes Based on Histological Tumor Necrosis and Predictive Clinical and Laboratory Parameters for Necrosis in Children With Osteosarcoma Treated on a Non-High Dose Methotrexate-Based Chemotherapy Backbone.
Badira Cheriyalinkal Parambil Poonam Khemani Ajay Puri Ashish Gulia Maya Prasad

Pediatr Blood Cancer

December 2024

Background: Histopathological response to neoadjuvant chemotherapy (NACT) measured as tumor necrosis (TN) has been reported to be prognostic post-high-dose methotrexate (HDMTX)-based chemotherapy. We studied this on a non-HDMTX chemotherapy backbone.

Materials And Methods: Children ≤15 years, with osteosarcoma treated on OGS-2012 protocol and surgery post NACT from January 2013 to December 2020 were retrospectively analyzed.

View Article and Find Full Text PDF
Privacy Policy Site Map

© LitMetric 2024. All rights reserved.