Publications by authors named "M Mungthin"
Article Synopsis
- Amphotericin B (AmB) is a strong antifungal and antiparasitic drug that kills leishmanial parasites by disrupting their cell membranes, making it important to study its effects on parasites like Leishmania orientalis to understand potential drug resistance.
- This study involved exposing a specific Leishmania orientalis strain to AmB and analyzing genetic changes through sequencing methods, focusing on single nucleotide polymorphisms (SNPs) and gene expression changes.
- The results indicated no significant chromosomal alterations post-treatment, but a higher incidence of SNPs in the control group, along with the downregulation of key genes, suggesting complex regulatory mechanisms might contribute to AmB resistance in this strain.
Purpose: To assess the clinical characteristics, progression patterns, and treatment outcomes of microbiologically confirmed microsporidial keratoconjunctivitis (MKC).
Methods: This prospective cross-sectional study included patients with superficial punctate epithelial keratitis clinically suspected of MKC. Comprehensive slit-lamp examinations were conducted, and corneal scraping was performed for Gram-chromotrope staining and polymerase chain reaction (PCR) analysis.
Objectives: This study aimed to enhance the learning experience among medical students by empowering them to co-create learning tools and classroom activities.
Methods: A cross-sectional study was conducted with 10 participants from Year 2 of the new curriculum volunteering to participate in this study. Five were selected based on their diversities and empowered to design learning tools and class activities.
Article Synopsis
- Leishmaniasis significantly affects the health of immunocompromised individuals, especially those with HIV, in Thailand, focusing on infections caused by Leishmania martiniquensis and Leishmania orientalis.
- A study conducted in Trang Province followed 506 HIV-infected participants from 2015-2019 to investigate the incidence and persistence of Leishmania infections, utilizing tests like Direct Agglutination Test and nested PCR.
- The findings revealed a 3.2% incidence rate in initially negative participants, with older age being a key risk factor, as well as a 3.7% persistence rate in those initially positive; all individuals were asymptomatic, highlighting the need for ongoing monitoring and targeted interventions.
Seasonal dynamics, Leishmania diversity, and nanopore-based metabarcoding of blood meal origins in Culicoides spp. in the newly emerging focus of leishmaniasis in Northern Thailand.
Parasit Vectors
September 2024
Article Synopsis
- There has been a rise in clinical cases of leishmaniasis in Southeast Asia, particularly in Thailand, with evidence suggesting that Culicoides biting midges play a significant role in transmitting Leishmania (Mundinia) parasites.
- A study conducted from 2021 to 2023 in Lampang Province, Northern Thailand, involved collecting and analyzing samples of Culicoides midges to understand their infection rates and host preferences.
- Results showed that 31 samples from various midge species tested positive for Leishmania, with a 5.7% infection rate, identifying six species as new potential leishmaniasis vectors, predominantly carrying Leishmania martiniquensis.