Publications by authors named "M Munera"
Autoimmune responses are characterized by the development of antibodies and the activation of T lymphocytes against self-antigens. This leads to an effector immune response against tissues expressing antigens, which are later recognized by the host immune system. Host antigens attacked by antibodies are called "autoantigens" and are of different kinds, including receptors, enzymes, and channel proteins.
View Article and Find Full Text PDFBackground: Atopic dermatitis (AD) is a chronic inflammatory skin condition that has a significant impact on quality of life. The immune response and allergy symptoms in AD are triggered by the recognition of specific allergens by IgE antibodies. Cross-reactivity can lead to auto-IgE responses, potentially worsening AD symptoms.
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- The study investigates changes in IgE sensitization to common allergens like dust mites, cats, dogs, and cockroaches over a 10-year period among patients with asthma, rhinitis, and atopic dermatitis.
- Results from 6,000 patient records indicate that 82% of individuals had sensitization to at least one allergen, with dust mites being the most common, and the exposure to certain allergens, such as Blomia tropicalis, increasing over time.
- The findings suggest that early exposure to dust mites is crucial for developing sensitization to other allergens, while exposure to pets, especially cats, is linked to a higher risk of developing atopy.
Introduction: This paper addresses the growing healthcare needs of an ageing population and the lack of advanced technologies with social capabilities that are cost effective, user friendly, and readily adopted. In response to this motivation, a socially assistive walker is designed to provide physical and cognitive support in activities of daily living for older adults.
Methods: Physical and cognitive support is provided by walker's structure, sensors, and feedback interfaces to assist users daily living activities, as well as, in navigating environment safely and efficiently.
Objective: Conduct an in-silico assessment of potential molecular mimicry between human aquaporins, , and diverse allergenic sources.
Methods: Amino acid sequences of human AQP3 and aquaporin were compared through multiple alignments with 25 aquaporins from diverse allergenic sources. Phylogenetic analysis and homology-based modeling were executed, and the ElliPro server predicted conserved antigenic regions on 3D structures.