Publications by authors named "M Mule"
The development of effective and safe vaccines and their timely delivery to the public play a crucial role in preventing and managing infectious diseases. Many vaccines have been produced and distributed globally to prevent COVID-19 infection. However, establishing effective vaccine development platforms and evaluating their safety and immunogenicity remains critical to increasing health security, especially in developing countries.
View Article and Find Full Text PDFArticle Synopsis
- - Echocardiography is a vital tool for doctors managing heart failure, especially in advanced heart failure (AdHF) patients, who face a high risk of death within a year.
- - There are treatments available that can improve outcomes for AdHF patients, potentially lowering mortality and postponing the need for serious interventions like heart transplants.
- - This review covers how echocardiography is used throughout the patient care process—from predicting AdHF and diagnosing it to guiding treatment decisions and assessing eligibility for advanced therapies.
Despite the innovations introduced in the 2022 European Society of Cardiology/European Respiratory Society Guidelines on Pulmonary Hypertension, risk discrimination and management of pulmonary arterial hypertension (PAH) patients at intermediate risk still represents a grey zone. Additionally, clinical evidence derived from currently available studies is limited. This expert panel survey intends to aid physicians in choosing the best therapeutic strategy for patients at intermediate risk despite ongoing oral therapy.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how the adjuvant AS03 affects vaccination responses in humans receiving the H5N1 influenza vaccine by analyzing data over 14 time points, including the immediate aftermath of the vaccination.
- Researchers developed a computational method to identify complex immune response patterns, revealing differences in how the immune system responds to the vaccine with and without the adjuvant at different stages of vaccination (prime and boost).
- Findings indicate that certain immune response signatures persist long after vaccination, and specific immune cell characteristics, particularly in monocytes and CD8 T cells, are associated with stronger antibody responses, suggesting that pre-existing immune states can influence vaccine effectiveness.
Aims: Sodium-glucose cotransporter inhibitors (SGLT2-i) improve outcomes in patients with heart failure (HF) and reduced ejection fraction (HFrEF). However, evidence in patients with advanced HF is lacking. We aimed to determine the effect of SGLT2-i in advanced HFrEF compared to their effect on a non-advanced population.
View Article and Find Full Text PDF