Publications by authors named "M Muehlbauer"
Objective: To characterize early physiologic stresses imposed by surgery by applying metabolomic analyses to deeply phenotype pre- and postoperative plasma and urine of patients undergoing elective surgical procedures.
Background: Patients experience perioperative stress through depletion of metabolic fuels. Bowel stasis or injury might allow more microbiome-derived uremic toxins to enter the blood, while the liver and kidney are simultaneously clearing analgesic and anesthetic drugs.
Article Synopsis
- The study investigates how SGLT2 inhibitors, particularly dapagliflozin, affect metabolism in patients with heart failure (HF) differing by ejection fraction (EF), focusing on ketone and fatty acid changes.
- It analyzed data from two trials involving 527 participants, using metabolomic profiling to identify the effects of dapagliflozin on various metabolites over 12 weeks.
- The findings revealed that dapagliflozin increased certain metabolites associated with ketosis and acylcarnitines but had less effect on amino acids, showing varying impacts depending on the patient's left ventricular ejection fraction.
Article Synopsis
- ChREBP is a key transcription factor that regulates genes involved in glucose, fructose, and lipid metabolism when carbohydrates are consumed, but its broader roles in metabolism need more research.* -
- In a study using liver-specific gene silencing in rats on a high-fat/sugar diet, suppressing ChREBP resulted in lower short-chain acyl CoA metabolites and decreased free CoA levels, affecting various metabolic enzyme expressions.* -
- Despite ChREBP knockdown enhancing fatty acid oxidation enzymes, the accumulation of liver acylcarnitines and ketones suggested a shift in metabolite processing, alongside maintained pyruvate levels due to increased transporter expression.*
Background: Severe acute malnutrition (SAM) can be diagnosed using weight-for-height Z-score (WHZ) and/or mid-upper arm circumference (MUAC). Although some favor using MUAC alone, valuing its presumed ability to identify children at greatest need for nutritional care, the functional severity and physiological responses to treatment in children with varying deficits in WHZ and MUAC remain inadequately characterized.
Objective: We aimed to compare clinical and biochemical responses to treatment in children with 1) both low MUAC and low WHZ, 2) low MUAC-only, and 3) low WHZ-only.
Article Synopsis
- Regular physical activity is essential for overall health, but understanding how endurance exercise affects molecular signaling is still a work in progress.
- The MoTrPAC project aims to explore these molecular responses by conducting structured endurance training on Fischer 344 rats of different ages and sexes, analyzing various tissues and other biological samples.
- The study found significant improvements in muscle function and fitness markers within just a few weeks of exercise, highlighting age- and sex-related differences and providing valuable resources for future research on exercise responses.