Impact of childhood asthma on growth trajectories in early adolescence: Findings from the Childhood Asthma Prevention Study (CAPS).

Background And Objective: Understanding the associations between childhood asthma and growth in early adolescence by accounting for the heterogeneity of growth during puberty has been largely unexplored. The objective was to identify sex-specific classes of growth trajectories during early adolescence, using a method which takes the heterogeneity of growth into account and to evaluate the association between childhood asthma and different classes of growth trajectories in adolescence.

Methods: Our longitudinal study included participants with a family history of asthma born during 1997-1999 in Sydney, Australia.

IGFBP-1 predicts all-cause mortality in elderly women independently of IGF-I.

Objective: Previous studies on the insulin-like growth factor (IGF) system and mortality have shown ambiguous results. We investigated the association between IGF-I and insulin- like growth factor binding protein-1 (IGFBP-1) with all-cause mortality in an elderly female Swedish population.

Design And Methods: A prospective cohort study of elderly women (n=338) aged between 68 and 79 years (mean age 72 years) with a mean follow-up time of 9.

Malignant melanoma of the choroid in an infant with the dysplastic naevus syndrome.

A 7-month-old Algerian boy with numerous skin naevi from birth was found to have a malignant melanoma of the choroid, giving symptoms from the age of 3 months. The ocular and cutaneous tumours were shown to be melanocytic by a battery of histochemical tests and by electron microscopy. The rarity of the case is discussed on basis of the literature, and it is concluded that the case is unique because of the early age at which both the ocular tumour and the dysplastic naevus syndrome occurred.