Publications by authors named "M Motte"
Representational similarity analysis of neural patterns in childhood maltreatment.
Neuropsychopharmacology
November 2024
Comparison of a Whole-Brain Contrast-Enhanced 3D TSE T1WI versus Orbits Contrast-Enhanced 2D Coronal T1WI at 3T MRI for the Detection of Optic Nerve Enhancement in Patients with Acute Loss of Visual Acuity.
AJNR Am J Neuroradiol
July 2024
Background And Purpose: MR imaging is the technique of choice for patients presenting with acute loss of visual acuity with no obvious ophthalmologic cause. The goal of our study was to compare orbits contrast-enhanced 2D coronal T1WI with a whole-brain contrast-enhanced 3D (WBCE-3D) TSE T1WI at 3T for the detection of optic nerve enhancement.
Materials And Methods: This institutional review board-approved retrospective single-center study included patients presenting with acute loss of vision who underwent 3T MR imaging from November 2014 to February 2020.
Article Synopsis
- Optic nerve head edema (ONHE) is commonly found in patients with optic neuritis (ON) and its connection to MRI abnormalities is not well understood, prompting this study to examine how effectively T2 FLAIR MRI can identify ONHE in acute ON cases.
- This study analyzed data from 102 patients with acute ON and found a high agreement (92%) between MRI findings and fundus photography, indicating that MRI can reliably detect ONHE.
- The research concluded that T2 FLAIR MRI is a sensitive and specific method for diagnosing ONHE, which can aid in the assessment of patients with optic neuritis.
In the search for novel influenza inhibitors we evaluated 7-fluoro-substituted indoles as bioisosteric replacements for the 7-azaindole scaffold of Pimodivir, a PB2 (polymerase basic protein 2) inhibitor currently in clinical development. Specifically, a 5,7-difluoroindole derivative was identified as a potent and metabolically stable influenza inhibitor. demonstrated a favorable oral pharmacokinetic profile and in vivo efficacy in mice.
View Article and Find Full Text PDFBackground: Predicting the risk of flares in patients with gout is a challenge and the link between urate burden and the risk of gout flare is unclear. The objective of this study was to determine if the extent of monosodium urate (MSU) burden measured with dual-energy computed tomography (DECT) and ultrasonography (US) is predictive of the risk of gout flares.
Methods: This prospective observational study recruited patients with gout to undergo MSU burden assessment with DECT (volume of deposits) and US (double contour sign) scans of the knees and feet.