Publications by authors named "M Motoi"
Royal sun medicinal mushroom Agaricus brasiliensis KA21 has various beneficial pharmacological effects; however, these effects are influenced by its cultivation conditions. A. brasiliensis KA21 is rich in β-glucan, which promotes wound healing.
View Article and Find Full Text PDFBrazil-grown outdoor-cultivated Agaricus brasiliensis KA21 fruiting body (KA21) significantly increases the production of serum anti-beta-glucan antibody. Therefore, KA21 ingestion may be useful for the prevention and alleviation of fungal infections. This study aimed to determine the effects of KA21 in fungal infections in animals.
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- The study investigates the role of specific β-adrenergic receptor (β-AR) gene variants in regulating brown adipose tissue (BAT) thermogenesis, which could play a significant role in combating obesity and metabolic issues in humans.
- Researchers analyzed genetic variants (single nucleotide polymorphisms) in 399 Japanese adults and validated findings in two independent groups to assess BAT activity under mild cold exposure using advanced imaging techniques.
- A significant association was found between a specific SNP in the β2-AR gene (ADRB2) and increased BAT activity, while no associations were observed for variants in the β1-AR and β3-AR genes, highlighting the critical role of β2-AR in cold-induced thermogenesis.
Article Synopsis
- The study examines how lowlanders' bodies respond to hypobaric hypoxia (HH), simulating high-altitude conditions for 75 minutes in a controlled chamber.
- Significant changes were observed: levels of aldosterone and cortisol decreased, while inflammatory markers like interleukin (IL)-6 and IL-8, along with white blood cell counts, increased after HH exposure.
- The research indicates that even brief exposure to HH triggers notable endocrine and immune responses, especially in individuals with lower peripheral oxygen saturation (SpO), enhancing our understanding of physiological adaptations to low-oxygen environments.