Publications by authors named "M Mothilal"
Objective: The study aimed to address the limitations of oral delivery and enhance the bioavailability of Cilnidipine (often prescribed as antihypertensive drug) (CND) through the development of transdermal patches containing ultra-deformable transferosomes.
Methods: CND, known for its low oral bioavailability and adverse effects, was encapsulated in transferosomes using a thin film hydration method. Seventeen formulations were made (using Box Behnken Design), varying Soya lecithin, Tween-80, and rotary evaporator's speed, and evaluated for vesicle size, polydispersity index (PDI), and entrapment efficiency (EE %).
Article Synopsis
- The study involves synthesizing iron oxide (γFeO) nanoparticles using a hydrothermal method and encapsulating them with doxorubicin (Dox) using natural almond gum.
- Characterization techniques like X-ray diffraction confirmed the crystal structure and highlighted superparamagnetic properties, while various analyses demonstrated the nanoparticles' morphology and heating capabilities.
- Drug release tests indicated that the nanoparticles are more effective in acidic conditions, and in vitro studies assessed their uptake and impact on HeLA cell lines.
Introduction: Nerve entrapment while suturing a lacerated wound is a complication that is easily avoidable. We report a case low ulnar nerve palsy due to nerve entrapment while suturing a lacerated wound.
Case Report: A 48 year old lady came with complaints of pain and a lacerated wound over the dorsomedial aspect of lower third of the left forearm.