Rapid Development of Unclassified Myeloid Lineage Acute Leukaemia With Trisomy 6 and U2AF1 Mutation.

We present a case of acute clonal bone marrow 98% infiltration of atypical myeloid cells with borderline hypogranular/agranular promyelocytes/myelocytes and occasional blast cells maturity, which also formed extramedullary tumours in the chest wall, with isolated trisomy of chromosome 6 and pathogenic variant U2AF1 (S34F) that escapes established acute myeloid leukaemia (AML) diagnostic criteria according to the World Health Organization (WHO) classification. Following standard daunorubicin and cytarabine induction therapy, the disease progressed with the appearance of a previously undetected clone of leukaemic cells with a distinct immunophenotype demonstrating monocytoid differentiation and clonal evolution to a hypo-tetraploid karyotype with an average number of 84 chromosomes and new pathogenic NRAS and ZRSR2 mutations. The patient reactivated refractory disseminated intravascular coagulation (DIC) leading to a progressive supratentorial hematoma and finally cardiac arrest.

Improper ferroelastic phase transition in a hydrogen-bonded metallocyanide-based (azetidinium)(HO)[Co(CN)] framework.

A hydrogen-bonded metallocyanide-based (AZE)(HO)[Co(CN)] framework was obtained by introducing a hydronium cation to the AB(1)B(2)CN-type structure. Simple K/HO substitution exchange the three-dimensional structure of the double-perovskite into two-dimensional layers containing open inorganic cages with a strongly discontinuous improper ferroelastic phase transition.

Phase transition tuning by Fe(iii)/Co(iii) substitution in switchable cyano-bridged perovskites: (CHN)[KFeCo(CN)].

The single-crystals of mixed (CHN)[KFeCo(CN)] crystals, with different ratios of x = 0, 0.29, 0.42, 0.

Structural phase transitions coupled with prominent dielectric anomalies and dielectric relaxation in [(CH)NH][KCo(CN)] and mixed [(CH)NH][KFeCo(CN)] double perovskite hybrids.

The crystals of pure [(CH)NH][KFe(CN)] (TrMAFe) and [(CH)NH][KCo(CN)] (TrMACo) as well as their mixed crystals (TrMAFeCo), with different ratios of x = 0, 0.12, 0.18, 0.

Multifunctional materials based on the double-perovskite organic-inorganic hybrid (CHNH)[KCr(CN)] showing switchable dielectric, magnetic, and semiconducting behaviour.

Herein, we have synthesised and characterised a novel organic-inorganic hybrid crystal, [CHNH]KCr(CN) (MACr). Thermal analysis (DSC, TGA-DTA) indicates one structural phase transition (PT) at 450 K. The modified equation of the tolerance factor, t, was used to estimate the theoretical PT temperature for a crystal with Mn(iii).