Publications by authors named "M Moseley"
Article Synopsis
- The study investigated the link between ADHD medication treatment and prescription stimulant misuse (PSM) among college students across 395 universities from Fall 2019 to Fall 2022.
- Among 224,469 undergraduates, 9.6% had an ADHD diagnosis, 5.1% were treated with medication, and 2.4% reported misusing stimulants in the past three months.
- Results indicated that for every 1% increase in university-level ADHD medication prevalence, PSM increased by 7%, highlighting a potential concern regarding stimulant misuse in relation to ADHD treatment rates.
Article Synopsis
- The study aims to improve prediction of 90-day functional outcomes in ischemic stroke patients using a deep learning model that combines non-contrast CT images and clinical data, potentially aiding healthcare planning and clinical trials.
- The dataset included 1,335 patients from multiple trials and registries, and the model demonstrated superior accuracy in predicting outcomes compared to models using only imaging or clinical data alone.
- The fused model achieved a mean absolute error (MAE) of 0.94 for mRS score prediction and an AUC of 0.91 for identifying unfavorable outcomes, indicating it significantly outperforms existing methods.
Article Synopsis
- - Zuranolone is a new oral treatment for postpartum depression, explored in a trial assessing its cognitive effects, safety, and pharmacokinetics when taken alone or with alprazolam or ethanol.
- - In the study, participants showed small-to-moderate cognitive decline when taking zuranolone, with greater declines observed when it was combined with alprazolam or ethanol.
- - Despite the cognitive effects, the study found no significant pharmacokinetic interactions between zuranolone and the other substances, though prescribers should note the heightened risk of CNS depression when used together.
Effects of zuranolone on next-day simulated driving in healthy adults.
Psychopharmacology (Berl)
February 2025
Article Synopsis
- Zuranolone is a medication that affects GABA receptors in the brain and could influence activities that require focused thinking, like driving.
- In a study involving 67 healthy adults, participants were given either zuranolone or a placebo, and their driving performance was measured using a simulator, focusing on how much the car swerved (standard deviation of lateral position, SDLP).
- Results showed that zuranolone significantly impaired driving performance and cognitive abilities shortly after dosing, with effects persisting even after a week of treatment, highlighting the need for caution when prescribing the drug.