Publications by authors named "M Moschetti"
Article Synopsis
- * Recent research has improved understanding of PD, emphasizing the need for timely diagnosis and highlighting a study of 2934 Italian subjects to gather new data on the disease.
- * Genetic analysis identified 39 symptomatic PD patients with low enzyme levels and specific mutations, along with 22 individuals with uncertain genetic variants, underscoring the variability in PD presentation.
Improving equity in undergraduate STEM is a national imperative. Although there is a rapidly growing body of research in this area, there is still a need to generate empirical evidence for equitable teaching techniques. We ground our work in Complex Instruction, an extensively researched pedagogical approach based on sociological theories and the malleability of status.
View Article and Find Full Text PDFThe release of extracellular vesicles (EVs) in cell cultures as well as their molecular cargo can be influenced by cell culture conditions such as the presence of foetal bovine serum (FBS). Although several studies have evaluated the effect of removing FBS-derived EVs by ultracentrifugation (UC), less is known about the influence of FBS heat inactivation (HI) on the cell-derived EVs. To assess this, three protocols based on different combinations of EV depletion by UC and HI were evaluated, including FBS ultracentrifuged but not heat inactivated (no-HI FBS), FBS heat inactivated before EV depletion (HI-before EV-depl FBS), and FBS heat inactivated after EV depletion (HI-after EV-depl FBS).
View Article and Find Full Text PDFLemon essential oil (LEO) is known for its aromatic and healthy properties; however, less consideration is given to the biological properties of the fractions obtained from LEO. This study aims to evaluate the ability of a citral-enriched fraction obtained from LEO (Cfr-LEO) to counteract lipopolysaccharide (LPS)-mediated inflammation, oxidative stress, and epithelial-mesenchymal transition (EMT) in healthy human hepatocytes. Human immortalized hepatocytes (THLE-2 cell line) were pretreated with Cfr-LEO and subsequently exposed to LPS at various time points.
View Article and Find Full Text PDFArticle Synopsis
- Pompe disease (PD) is a rare genetic disorder characterized by a deficiency in the enzyme acid α-glucosidase, leading to glycogen buildup and progressive muscle weakness, particularly affecting skeletal muscles and the nervous system.
- A clinical case of late-onset PD (LOPD) was diagnosed after the patient was misdiagnosed with other conditions, highlighting the necessity for thorough investigations including genetic and enzymatic studies.
- The findings underscore the importance of recognizing the diverse clinical manifestations of PD, which can resemble other muscle disorders, and suggest the need for further research into the disease's clinical spectrum.