Dietary variety and the relationship between polypharmacy and incident disability among Japanese community-dwelling older adults: A longitudinal study.

Objectives: This study examined the association between polypharmacy and incident disability across the dietary variety score (DVS) strata among community-dwelling older adults.

Study Design: A prospective cohort study with community-dwelling adults aged ≥65 in Aichi, Japan.

Main Outcome Measures: Polypharmacy was defined as ≥5 concomitant prescription drugs per day.

Community-based going-out program and dementia onset in Japanese older adults: A longitudinal observational study.

Objectives: With dementia prevalence rising globally among older adults, effective and scalable community-based interventions are urgently needed to reduce dementia onset. This study aimed to estimate the association of the going-out program with dementia onset in older adults.

Methods: A 5-year longitudinal observational study was employed.

Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts.

Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left ventricular reverse remodeling (LVRR). Currently, the detailed association between genotypes and clinical outcomes, including LVRR, particularly among children, remains uncertain.

Engagement in the community-based going-out programs and the association with physical frailty assessed by the Kihon Checklist: A cohort study.

Introduction: In efforts to address the public health concern of physical frailty prevention, community-based programs without supervision are anticipated, yet efficacy has not been shown. We aimed to investigate the association of engaging in an unsupervised, community-based going-out program on the incidence of physical frailty among older adults.

Methods: A cohort observational study was employed.

Effects of high-pressure-processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in hyperglycemic older people.

Purpose: High-pressure-processed (HPP) rice is white rice that maintains some key functional food ingredients of brown rice, such as polyphenols. We examined whether HPP rice intake during interval walking training (IWT) improved glycemic control with enhanced methylation of the NFKB2 gene in hyperglycemic older subjects.

Methods: We recruited 51 people aged ~ 70 yr who had already performed IWT for ≥ 6 months, but had hyperglycemia (blood glucose concentration ([Glc]) > 110 mg/dl or HbA1c > 6.