Publications by authors named "M Morelle"
Background: Whether re-excision (RE) of a soft tissue sarcoma (STS) of limb or trunk should be systematized as adjuvant care and if it would improve metastatic free survival (MFS) are still debated. The impact of resection margins after unplanned macroscopically complete excision (UE) performed out of a NETSARC reference center or after second resection was further investigated.
Methods: This large nationwide series used data from patients having experienced UE outside of a reference center from 2010 to 2019, collected in a French nationwide exhaustive prospective cohort NETSARC.
Background And Purpose: We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore to decrease xerostomia, when compared to a standard IMRT.
Materials And Methods: We conducted the ARTIX trial, a randomized, parallel-group, multicentric study comparing a systematic weekly replanning ART to a standard IMRT. The primary endpoint was the frequency of xerostomia at 12 months, measured by stimulating salivary flow with paraffin.
Background: We investigated the impact of the implementation of a network of reference centers for sarcomas (NETSARC) on the care and survival of sarcoma patients in France since 2010.
Patients And Methods: NETSARC (netsarc.org) is a network of 26 reference sarcoma centers with specialized multidisciplinary tumor boards (MDTBs), funded by the French National Cancer Institute (INCa) since 2010.
Epithelioid Hemangioendothelioma: A NATIONWIDE STUDY: Epithelioid hemangioendothelioma (EHE) is an ultrarare sarcoma whose natural history and treatment is not well defined. We report on the presentation and outcome of 267 patients with EHE in the NETSARC+ network since 2010 in France.
Patients And Methods: NETSARC (netsarc.
Article Synopsis
- The study utilized the NETSARC database to analyze management and outcomes of adolescents and young adults (AYAs) with sarcoma in France from 2010 to 2017, focusing on surgical cases.
- Findings showed significant discrepancies in adherence to treatment guidelines between patients treated at reference sarcoma centers (RSC) and non-reference centers (non-RSC), with RSC having better rates of crucial pre-treatment procedures.
- Despite similar overall survival rates (OS) for AYAs in both settings, those treated in RSC had notably better locoregional recurrence-free survival (LRFS) and progression-free survival (PFS), underscoring the benefits of multidisciplinary care in specialized centers.