Publications by authors named "M Moravek"
Purpose/aim: Some youth seek puberty suppression to prolong decision-making prior to starting hormone therapy to help align their physical sex characteristics with their gender identity. During peripubertal growth, connective tissues such as tendon rapidly adapt to applied mechanical loads (e.g.
View Article and Find Full Text PDFStudy Question: How does testosterone gender-affirming hormone therapy (T-GAHT) impact breeding success in female mice?
Summary Answer: T-GAHT causes reversible subfertility in female mice and persistent changes to reproductive tract anatomy, gene expression, and hormone receptors.
What Is Known Already: Adult female mice implanted with capsules containing 10 mg of testosterone mimic many aspects of reproductive phenotypes of T-GAHT patients, who may desire future gestation while pausing T-GAHT. In mice, oocytes retrieved from T-GAHT mice had decreased IVF rates, and T cessation prior to stimulation improved these outcomes.
The diffusive gradient in thin films technique (DGT), with a resin gel based on Lewatit® FO 36 was used for the first time to predict arsenic (As) bioavailability in soils collected in different environmental contexts. The predicted bioavailability, determined by fluxes to DGT, was compared with the bioavailability and bioaccumulation in the plants (Calendula officinalis), where a strong correlation was observed (r = 0.8857 (C/C) and r = 0.
View Article and Find Full Text PDFArticle Synopsis
- Osteoarthritis (OA) is common and currently lacks effective treatments that can both modulate the immune response and repair cartilage, prompting research into extracellular vesicles (EVs) from blood-derived products like platelet poor plasma (PPP).
- This study examined how PPP-derived EVs affect OA chondrocytes in a lab setting, revealing that these EVs possess anti-inflammatory properties and can significantly reduce the expression of certain inflammatory genes associated with OA.
- The findings suggest that PPP-EVs can potentially be developed as a new type of treatment for OA, offering promise for better management of the disease in the future.
Background: To better understand informal coping strategies among adolescents and young adults (AYAs) with cancer, the current investigation asked AYA study participants to describe the 'advice' they would offer to hypothetical peers about coping following diagnosis. This study explores the utility of the single item 'advice' prompt for supportive oncology research and practice.
Methods: AYA cancer patients (n = 27) aged 12-25 years were recruited through electronic health record query at a single-institution health system.