3-methoxycatechol causes vasodilation likely via K channels: ex vivo, in silico docking and in vivo study.

Substituted catechols include both natural and synthetic compounds found in the environment and foods. Some of them are flavonoid metabolites formed by the gut microbiota which are absorbed afterwards. Our previous findings showed that one of these metabolites, 4-methylcatechol, exerts potent vasorelaxant effects in rats.

New approach and strategy in the assessment of labour pain - Czech version of the labour coping pain assessment tool.

Objectives: To create a Czech version of the Labor Coping Scale (LCS) evaluation tool intended for midwives when caring for a woman with labor pain, to evaluate its psychometric properties and to find out the opinion on it in clinical practice.

Materials And Methods: Are use a combination of methods. By using repeated back translation, the Czech version of the LCS tool was created.

When time does not heal all wounds: three decades' experience of immigrants living in Sweden.

Aim: To investigate how immigrants from the Balkan region experienced their current life situation after living in Sweden for 30 years or more.

Materials: The study was designed as a qualitative study using data from interviews with informants from five Balkan countries. The inclusion criteria were informants who were immigrants to Sweden and had lived in Sweden for more than 30 years.

3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes.

Cobalt intoxication can occur after its release from metal-based prostheses, which is generally clinically severe. Therefore, there is a need for the development of a cobalt chelator since there are currently no approved drugs for cobalt intoxication. As flavonoids are known for their metal chelating properties and safety, the screening of cobalt chelating properties was performed in a total of 23 flavonoids by our recently developed new spectrophotometric assay.