Hydrothorax and air fluid levels in the right chest - a diagnostic dilemma.

A diaphragmatic defect that permits abdominal contents to herniate into the right side of the chest is rare. In adults with right-sided diaphragmatic hernias, few occur without a history of trauma, and even fewer are symptomatic. This case report illustrates such a case and the rare entity of an anterolaterally located hernia.

Effects of small molecule-induced dimerization on the programmed death ligand 1 protein life cycle.

The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) checkpoint blockade is central to Immuno-Oncology based therapies, and alternatives to antibody blockers of this interaction are an active area of research due to antibody related toxicities. Recently, small molecule compounds that induce PD-L1 dimerization and occlusion of PD-1 binding site have been identified and developed for clinical trials. This mechanism invokes an oligomeric state of PD-L1 not observed in cells previously, as PD-L1 is generally believed to function as a monomer.

Lower Extremity Salvage in a Diabetic Patient With Cutaneous Mucormycosis and COVID-19 After Open Patella Fracture.

Cutaneous mucormycosis, while less common than sinonasal or pulmonary infections, can cause widespread tissue necrosis after seemingly innocuous encounters. The most common location of cutaneous mucormycosis is the extremities, and extensive infection has been reported after trauma or orthopedic procedures. A 60-year-old female with poorly controlled type 2 diabetes mellitus sustained an open patella fracture after a fall.

Mind the gap - unequal from the start: evidence from the early years of the longitudinal study.

is this country's largest contemporary longitudinal study of child development. The study has been designed to provide insight into the lives of children and young people growing up in the context of twenty-first century New Zealand. The cohort recruited 6853 children representative of the current ethnic and socioeconomic diversity of births in Aotearoa, New Zealand in 2009 and 2010.

The potential impact of an implemented income redistribution package on obesity prevalence in New Zealand.

Aim: This study quantified associations between (absolute and relative) individual income and obesity prevalence. These associations were then used to model the potential effect of a New Zealand (NZ) Government's income redistributive policy (the Families Package) on adult obesity prevalence.

Methods: Logistic regressions were used to investigate associations between absolute individual income and adult obesity prevalence in NZ.