Publications by authors named "M Montelongo"
Purpose: To evaluate patient-reported health-related quality-of-life (QoL) in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced/metastatic breast cancer (ABC) treated with palbociclib in the longitudinal real-world study, POLARIS.
Methods: Data were prospectively collected from adult patients with HR+/HER2- ABC treated with palbociclib plus endocrine therapy (ET) in routine clinical practice. QoL was assessed with the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire-Core 30 (EORTC QLQ-C30) and reported at baseline and months 6, 12, and 18.
Article Synopsis
- Strict eligibility criteria in RCTs limit data applicability to diverse real-world populations; thus, the POLARIS study focuses on hormone receptor-positive/HER2-negative advanced breast cancer patients receiving palbociclib and endocrine therapy.
- The study analyzed demographic and treatment data from 1,250 patients over a span of nearly three years, reporting response rates of 34.0% in first-line treatment and 21.8% in later lines, with median progression-free survival and overall survival varying by treatment line.
- Results indicate that outcomes in this diverse population align with previous clinical trial data, reinforcing the efficacy of palbociclib combined with endocrine therapy for patients with HR+/HER2- advanced breast cancer.
Phylodynamic Insights into Global Emergence and Diversification of the Tomato Pathogen pv. .
Mol Plant Microbe Interact
October 2024
The emergence of plant pathogens is often associated with waves of unique evolutionary and epidemiological events. pv. is one of the major pathogens causing bacterial spot disease of tomatoes.
View Article and Find Full Text PDFTetanus is a preventable, yet often fatal, disease affecting many species, including beef cattle. Vaccination for tetanus is recommended for calves at high risk of disease, but typical beef cattle management practices often make adherence to vaccine manufacturers' guidance for a second (booster) dose of vaccine difficult. This study examined the antibody response following a single dose of tetanus toxoid, as well as following booster vaccination at various intervals.
View Article and Find Full Text PDFBackground: Substance misuse is a major public health issue and research has established attenuated reward responses to drug cues in those who misuse substances. Yet, little is known about whether the expectation of natural reinforcers engages distinct brain regions in substance misuse.
Methods: Using functional magnetic resonance imaging (fMRI), we delivered juice at expected and unexpected times to examine reward processing dysfunctions.