Publications by authors named "M Montalto"
Deployment of a Machine Learning Algorithm in a Real-World Cohort for Quality Control Monitoring of Human Epidermal Growth Factor-2-Stained Clinical Specimens in Breast Cancer.
Benjamin Glass Michel E Vandenberghe Surya Teja Chavali Syed Ashar Javed Murray Resnick Michael Montalto
Arch Pathol Lab Med
December 2024
Context.—: Precise determination of biomarker status is necessary for clinical trial enrollment and endpoint analyses, as well as for optimal treatment determination in real-world practice. However, variabilities may be introduced into this process due to the processing of clinical specimens by different laboratories and assessment by distinct pathologists.
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- Metabolic dysfunction-associated steatohepatitis (MASH) is a serious liver condition with limited treatment options and relies on manual biopsies for assessment, which often shows high variability among readers.
- A new artificial intelligence (AI) system, AIM-MASH, has been developed and validated across multiple sites to assist pathologists in scoring liver biopsies related to MASH, showing high reliability and consistency compared to traditional methods.
- AIM-MASH significantly improved the accuracy of assessing key factors like inflammation and MASH resolution when used by expert pathologists, suggesting it can reduce variability and enhance the evaluation of new treatments in MASH clinical trials.
Article Synopsis
- The study investigates the link between long COVID gastrointestinal symptoms and post-infection gut-brain interaction disorders, aiming to uncover the mechanisms behind these long-term issues.
- Eighty-six individuals who recovered from SARS-CoV-2 infection were evaluated for GI symptoms, inflammation, and permeability, with specific questionnaires used to assess their conditions.
- Results indicated that 43% of participants reported long-term GI symptoms, but those without symptoms had higher intestinal inflammation levels, suggesting local inflammatory mechanisms may not be the primary cause of GI complaints in long COVID.
Article Synopsis
- Acute diarrhea is a significant public health challenge, particularly in emergency departments (EDs), and managing these patients effectively is complex.
- A study of over 20,000 patients revealed that factors like age over 65, prolonged symptoms, and certain health histories were linked to higher chances of returning to the ED after discharge.
- Guidelines suggest a thorough evaluation of patient history and health conditions to tailor treatment, as the choice of antibiotics and other medications can affect readmission rates, especially in different age demographics.
Article Synopsis
- - The standard method for assessing metabolic dysfunction-associated steatosis in clinical trials is by evaluating liver biopsies on glass slides; however, shipping these slides poses logistical challenges and risks of damage.
- - This study found that using digital images on the AISight whole slide image management system for assessing steatohepatitis offers comparable accuracy to traditional glass slide evaluations, with both methods verified against a consensus score from expert pathologists.
- - The results showed that the agreement between digital scoring and the established "ground truth" was not inferior to that of glass scoring, indicating that digital assessments can reliably replace traditional methods in clinical trial settings for liver disease.