Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene.

CXCR4, a chemokine receptor known as Fusin or CD184, spans the outer membrane of various human cells, including leukocytes. This receptor is essential for HIV infection as well as for many vital cellular processes and is implicated to be associated with multiple pathologies, including cancers. This study employs various computational tools to investigate the molecular effects of disease-vulnerable germ-line missense and non-coding SNPs of the CXCR4 gene.

Dithiocarbamate as a Carbonyl Alternative in Pd-Catalyzed Carbonylative Homocoupling of Organoboronic Acids.

We have developed a novel protocol for carbonylative homocoupling of arylboronic acids using dithiocarbamate esters as the carbonyl alternative. A series of arylboronic acids underwent smooth reaction with dithiocarbamate ester (MeNCSMe) in the presence of Pd(PPh)Cl catalyst, Cu(OAc)·HO additive, and NaCO in DCE solvent, producing the biaryl ketones efficiently. The mechanism has been studied with the help of several control experiments that reveal the probability of thioamide intermediacy.

Convective heat transport in a porous wavy enclosure: Nonuniform multi-frequency heating with hybrid nanofluid and magnetic field.

This work investigates the dynamics of the hybrid nanofluidic convective heat transfer in a permeable thermal system under the influence of multifrequency heating and a magnetic field. The geometry comprises a wavy-walled cavity filled with a water-based hybrid nanoliquid (AlO-Cu-HO) in a saturated porous medium. The finite volume approach is applied to scrutinize the hydro-thermal characteristics resulting from bottom heating and side cooling, considering various flow-controlling parameters.

A rare case of complicated typhoid fever presenting with secondary Hemophagocytic Lymphohistiocytosis.

Enteric fever is one of the important causes of tropical fever with a prevalence of 11-21 million cases worldwide annually. It encompasses both typhoid and paratyphoid fever. Typhi is the causative organism for typhoid fever, manifesting as an uncomplicated febrile illness to life-threatening sepsis with multiorgan dysfunction.

Pulmonary thromboembolism-a rare presentation for Strongyloides hyperinfection in an immunocompetent patient.

is an intestinal nematode. It is widely distributed in the tropics and sub-tropics of the world. It can cause a wide array of illnesses ranging from asymptomatic autoinfection to a severe form of hyperinfection and disseminated strongyloidiasis.