Publications by authors named "M Molitch"
Introduction: Tubular biomarkers may shed insight into progression of kidney tubulointerstitial pathology complementary to traditional measures of glomerular function and damage.
Methods: We examined trajectories of tubular biomarkers in the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC Study) of type 1 diabetes (T1D). Biomarkers were measured in a subset of 220 participants across 7 time points over 26 years.
Objective: Tubulointerstitial injury contributes to diabetic kidney disease (DKD) progression. We tested tubular biomarker associations with DKD development in type 1 diabetes (T1D).
Research Design And Methods: We performed a case-cohort study examining associations of tubular biomarkers, measured across seven time points spanning ∼30 years, with incident macroalbuminuria ("severely elevated albuminuria," urinary albumin excretion rate [AER] ≥300 mg/day) and sustained low estimated glomerular filtration rate (eGFR) (persistent eGFR <60 mL/min/1.
Article Synopsis
- A study analyzed infection and rejection outcomes in liver and heart transplant patients based on their postoperative insulin resistance, measured by peak insulin drip rates.
- In liver transplant patients (n = 207), those in the highest insulin drip quartile (Q4) experienced significantly fewer infections (42.3% vs. 60.0%) and borderline fewer rejection episodes (25.0% vs. 40.0%) compared to lower quartiles.
- Similarly, heart transplant patients (n = 188) in Q4 had significantly fewer infections (19.1% vs. 53.9%). The study suggests that a stronger counter-regulatory response to insulin resistance might correlate with better infection response and overall health.
Objective: To describe a practical approach of when and how often to perform imaging, and when to stop imaging pituitary adenomas (PAs).
Methods: A literature review was carried out and recommendations provided are derived largely from personal experience.
Results: Magnetic resonance imaging is the mainstay imaging modality of choice in the assessment, treatment planning, and follow-up of PAs.