Publications by authors named "M Molina-Alarcon"
Article Synopsis
- The study focuses on the synthesis of five small molecules featuring a guanidine core through guanylation reactions, a key method in medicinal chemistry.
- These compounds were tested against various strains of bacteria, including extended-spectrum beta-lactamase (ESBL) producers and methicillin-resistant Staphylococcus aureus (MRSA), using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests.
- Results indicate that these guanidine-core molecules show potential as new treatments for bacterial infections, especially against drug-resistant strains, suggesting further research is necessary to optimize their effectiveness.
To develop a predictive model for successful cervical ripening in women that undergo induction of labour by means of a vaginal prostaglandin slow-release delivery system (Propess®). Prospective observational study on 204 women that required induction of labour between February 2019 and May 2020 at "La Mancha Centro" hospital in Alcázar de San Juan, Spain. The main variable studied was effective cervical ripening (Bishop score > 6).
View Article and Find Full Text PDFNanotechnology is a developing field that has boomed in recent years due to the multiple qualities of nanoparticles (NPs), one of which is their antimicrobial capacity. We propose that NPs anchored with 2-(dimethylamino)ethyl methacrylate (DMAEMA) have antibacterial properties and could constitute an alternative tool in this field. To this end, the antimicrobial effects of three quaternised NPs anchored with DMAEMA were studied.
View Article and Find Full Text PDFObjectives: To determine whether the interaction between frailty status and depression risk is associated with hospitalization density in older adults.
Methods: Ongoing cohort study in 794 subjects aged over 70 years from Albacete (Spain). Data were collected on depression risk, frailty, hospitalizations, and covariates.
Purpose: To evaluate the effect and safety of vaginal dinoprostone in pregnant women with PROM who undergo induction of labor (IoL). Materials and Methods: Prospective observational study conducted at La Mancha Centro hospital from 1 February 2019, to 30 August 2020. Obstetric and neonatal variables of 94 pregnant women with PROM who underwent IoL with vaginal dinoprostone were analyzed, and the results were compared with 330 patients without PROM who also underwent IoL.
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