Publications by authors named "M Molefi"
Background: Drug-resistant tuberculosis (DR-TB) poses a significant global health challenge and requires treatment with potentially toxic second-line anti-TB drugs. Assessing the health-related quality of life (HRQoL) of DR-TB patients is crucial, given the impact of disease and treatment on their well-being. This study aimed to evaluate HRQoL among DR-TB patients undergoing treatment in Botswana and identify predictors of variability during the treatment period.
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- * The methodology includes translating the original tool, evaluating its validity and reliability with HIV outpatients, and using statistical models to analyze HRQoL predictors in various HIV sub-populations.
- * Ethical considerations include obtaining informed consent, ensuring confidentiality, and securely storing data, all of which are approved by multiple health and educational institutions in Botswana.
Article Synopsis
- The study evaluates the prevalence and risk factors of scabies and impetigo in the Nata and Sowa areas of the Tutume district, noting a significant lack of previous epidemiological data, especially in sub-Saharan Africa.
- A cross-sectional study revealed an overall scabies prevalence of 18.18%, with the highest rates in the communities of Manxhotae and Ndutshaa, while impetigo cases were rare.
- Key risk factors identified include younger age groups (0-4 years and 5-18 years) and having a household member with itching, indicating a need for more research on household transmission dynamics.
Background: Single, high-dose liposomal amphotericin B (LAmB; AmBisome, Gilead Sciences) has demonstrated non-inferiority to amphotericin B deoxycholate in combination with other antifungals for averting all-cause mortality from HIV-associated cryptococcal meningitis. There are limited data on the pharmacokinetics (PK) of AmBisome. The aim of this study was to describe population PK of AmBisome and conduct a meta-analysis of the available studies to suggest the optimal dosing for cryptococcal meningoencephalitis.
View Article and Find Full Text PDFIntroduction: key populations and transgender people in particular are at a high risk of HIV infection. However, very little is known about risk behaviors of transgender people in Botswana. The aim of this study was to determine the prevalence of high-risk behaviors for HIV and sexually transmitted infections (STIs) among transgender people in Botswana.
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