Publications by authors named "M Mohsen Ibrahim"
To assess the choroidal vessels in healthy eyes using a novel three-dimensional (3D) deep learning approach. In this cross-sectional retrospective study, swept-source OCT 6 × 6 mm scans on Plex Elite 9000 device were obtained. Automated segmentation of the choroidal layer was achieved using a deep-learning ResUNet model along with a volumetric smoothing approach.
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Purpose: To compare changes of vertical palpebral fissure height after bilateral lateral rectus (BLR) recessions versus unilateral lateral rectus (LR) recession and medial rectus (MR) muscle scleral plication, for treatment of intermittent exotropia.
Methods: This prospective, comparative, randomized study included 40 patients with intermittent exotropia who were divided into two groups: 20 patients who underwent BLR recessions (BLR recession group) and 20 patients who underwent unilateral LR recession and MR muscle scleral plication (recession-plication group). Eyelid evaluation included measurement of margin reflex distance 1 (MRD1) and margin reflex distance 2 (MRD2) at 1 week, 6 weeks, and 3 months postoperatively.
Undescribed cytotoxic butenolides; asperterreunolides A-E, isolated from endophytic fungus Aspergillus terreus derived from Artemisia arborescens L. supported with in silico study.
Phytochemistry
December 2024
Article Synopsis
- The ethyl acetate extract from the endophytic fungus Aspergillus terreus found in Artemisia arborescens L. led to the discovery of five new compounds, asperterreunolides A-E, along with a known metabolite, butyrolactone IV.
- Using advanced spectroscopic techniques, the researchers determined the structures and the absolute configurations of these metabolites.
- All isolated compounds exhibited significant cytotoxic effects against certain cancer cell lines, and molecular docking studies suggested their potential mechanism of action as inhibitors of type IIA topoisomerase.
Article Synopsis
- Methomyl (MET) is a widely used insecticide that causes significant harm to organs like the heart and lungs in humans and animals.
- Betaine (BET), a natural antioxidant, was tested for its protective effects against MET-induced damage in rats, revealing that MET causes oxidative stress and severe tissue damage while BET mitigates these harmful effects.
- The research concludes that BET shields against MET-induced cardiovascular injury and lung inflammation by influencing specific molecular pathways that reduce oxidative stress and inflammation.