Publications by authors named "M Modo"
Objective: Epilepsy is recognized increasingly as a network disease, with changes extending beyond the epileptogenic zone (EZ). However, more studies of structural connectivity are needed to better understand the behavior and nature of this condition.
Methods: In this study, we applied differential tractography, a novel technique that measures changes in anisotropic diffusion, to assess widespread structural connectivity alterations in a total of 42 patients diagnosed with medically refractory epilepsy (MRE), including 27 patients with focal epilepsy and 15 patients with multifocal epilepsy that were included to validate our hypothesis.
Article Synopsis
- The global rise in aging populations is linked to a higher incidence of Alzheimer's disease (AD) and its socioeconomic impacts, driven largely by abnormal amyloid-β (Aβ) metabolism.
- Current treatments focusing on Aβ removal have shown limited cognitive benefits, highlighting the complexity of AD's causes, which include a range of factors like tau accumulation, neuroinflammation, and vascular dysfunction.
- To effectively treat AD, extensive research is needed on neurodegeneration mechanisms, identifying intervention targets, and developing combinatorial treatment strategies, with the overarching goal of reversing cognitive decline through the Alzheimer's Disease Neuroprotection Research Initiative.
Matrix metalloproteinases (MMPs) cause proteolysis of extracellular matrix (ECM) in tissues affected by stroke. However, little is known about how MMPs degrade ECM hydrogels implanted into stroke cavities to regenerate lost tissue. To establish a structure-function relationship between different doses of individual MMPs and isolate their effects in a controlled setting, an in vitro degradation assay quantified retained urinary bladder matrix (UBM) hydrogel mass as a measure of degradation across time.
View Article and Find Full Text PDFThe connectivity of the hippocampus is essential to its functions. To gain a whole system view of intrahippocampal connectivity, ex vivo mesoscale (100 μm isotropic resolution) multi-shell diffusion MRI (11.7T) and tractography were performed on entire post-mortem human right hippocampi.
View Article and Find Full Text PDFPurpose: pH enhanced (pH ) CEST imaging combines the pH sensitivity from amide and guanidino signals, but the saturation parameters have not been optimized. We propose pH as a variant of pH that suppresses background signal variations, while enhancing pH sensitivity and potential for imaging ischemic brain injury of stroke.
Methods: Simulation and in vivo rodent stroke experiments of pH MRI were performed with varied RF saturation powers for both amide and guanidino protons to optimize the contrast between lesion/normal tissues, while simultaneously minimizing signal variations across different types of normal tissues.