Publications by authors named "M Modaresi"
Article Synopsis
- - The study investigates the prevalence of azole-resistant Aspergillus fumigatus (ARAf) in Iranian cystic fibrosis (CF) patients, noting that although common fungal infections include Candida species, ARAf poses a significant risk for severe lung infections.
- - Researchers collected and analyzed 120 sputum samples from 103 CF patients, finding that 84.2% were positive for filamentous fungi, with the majority being Aspergillus species and a smaller percentage being Candida species.
- - Among the Aspergillus isolates, 46.5% belonged to the Fumigati section, and 14 showed resistance to azole antifungals, indicating a 9% prevalence of ARAf in the total fungal
Cystic fibrosis (CF) is a genetic ailment caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This autosomal recessive disorder is characterized by diverse pathobiological abnormalities, such as the disorder of CFTR channels in mucosal surfaces, caused by inadequate clearance of mucus and sputum, in addition to the malfunctioning of mucous organs. However, the primary motive of mortality in CF patients is pulmonary failure, which is attributed to the colonization of opportunistic microorganisms, formation of resistant biofilms, and a subsequent decline in lung characteristics.
View Article and Find Full Text PDFArticle Synopsis
- The study discusses a rare lung disease in nine children linked to a genetic deficiency of the CCR2 receptor, leading to conditions like pulmonary alveolar proteinosis (PAP) and increased vulnerability to infections.
- This deficiency is characterized by loss-of-function variants, affecting the migration and signaling of immune cells, particularly monocytes, due to a lack of response to CCL-2, a chemokine essential for these processes.
- Elevated levels of CCL-2 in the blood serve as a diagnostic marker for identifying children with unexplained respiratory issues or recurrent infections, indicating the importance of CCR2 in lung health and immune response.
Comparison of culture and PCR-DGGE methods to evaluate the airways of cystic fibrosis patients and determination of their antibiotic resistance profile.
Iran J Microbiol
December 2023
Background And Objectives: Respiratory infections are the most serious condition in cystic fibrosis (CF) patients; therefore, a thorough comprehension of the diversity and dominant microbial species in CF airways has a crucial role in treatment. Our objective was to determine the antibiotic resistance profile of CF airways microbiota and compare culture methods and PCR-DGGE to evaluate bacterial diversity.
Materials And Methods: Pharyngeal swabs from 121 CF patients were collected.