Publications by authors named "M Moche"
Interventional oncology (IO) employs various techniques to enable minimally invasive, image-guided treatment of tumor diseases with both curative and palliative goals. Additionally, it significantly contributes to managing tumor-related and perioperative complications, offering diverse supportive procedures for patients at all stages of their diseases. The execution of IO procedures places unique demands on the equipment, personnel, and structural organization of radiological clinics, necessitating specific expertise from interventional radiologists.
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- The study investigates the use of degradable starch microspheres (DSMs) in uterine artery embolization (UAE) for treating fibroids, aiming to avoid severe side effects linked to nondegradable particles.
- Eight nonpregnant sheep were anesthetized and underwent UAE with DSMs, followed by angiographic evaluations on days 1, 3, and 7 to track recanalization and assess uterine damage.
- Results showed successful embolization with noticeable recanalization in most arteries and evidence of uterine necrosis, suggesting that DSMs effectively induce ischemic changes while allowing for later artery reopening.
screening of large compound libraries with automated high-throughput screening is expensive and time-consuming and requires dedicated infrastructures. Conversely, the selection of DNA-encoded chemical libraries (DECLs) can be rapidly performed with routine equipment available in most laboratories. In this study, we identified novel inhibitors of SARS-CoV-2 main protease (M) through the affinity-based selection of the DELopen library (open access for academics), containing 4.
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- KRAS is a small GTPase that acts as a switch for cell signaling, and mutations in KRAS are linked to various cancers, notably pancreatic, lung, and colorectal cancers.
- Recent efforts to target specific KRAS mutations, particularly G12C and G12D, have shown some success, but other mutations like G12V and G13D remain difficult to treat.
- The study presents a new KRAS G13D conformer structure that could be targeted by a developed monoclonal antibody, which effectively inhibited KRAS signaling in cancer cells, suggesting a new avenue for therapeutic development against this mutation.
Background: Hepatic chemosaturation is a technique in which a high dose of the chemotherapeutic agent melphalan is administered directly into the liver while limiting systemic side effects. We reviewed our institutional experience regarding patient's X-ray exposure caused by the procedure.
Methods: Fifty-five procedures, performed between 2016 and 2020 in 18 patients by three interventional radiologists (radiologist), were analyzed regarding the patient's exposure to radiation.