Publications by authors named "M Mitsuhashi"
Article Synopsis
- During recovery from spinal cord injury in macaques, the unaffected side of the sensorimotor cortex becomes crucial in controlling movements of the injured hand.
- Effective movement regulation involves not just sending motor commands directly to muscles, but also requires coordination with higher-level brain systems, like the cortico-basal ganglia and cortico-cerebellar loops.
- The study found that following injury, there was an increase in axonal projections from the affected motor cortex to key brain regions, suggesting these changes help activate the unaffected cortex to support movement recovery on the impaired side.
Whether and how the non-lesional sensorimotor cortex is activated and contributes to post-injury motor recovery is controversial. Here, we investigated the role of interhemispheric pathway from the contralesional to ipsilesional premotor cortex in activating the ipsilesional sensorimotor cortex and promoting recovery after lesioning the lateral corticospinal tract at the cervical cord, by unidirectional chemogenetic blockade in macaques. The blockade impaired dexterous hand movements during the early recovery stage.
View Article and Find Full Text PDFThe myelin sheath surrounding axons is vulnerable to mechanical stresses after head injuries, as well as autoimmune attacks and degeneration in neurological disorders. Unfortunately, there is currently no effective method to assess these axonal conditions in individual patients. We have developed a sandwich immunoassay detecting dual signals of myelin oligodendrocyte glycoprotein (MOG) and interleukin 1B (IL1B) in human plasma ([IL1B on MOG]).
View Article and Find Full Text PDFWe sought to identify alterations in the quantity of plasma brain-derived extracellular vesicles (EV) over the first month post-stroke to shed light on related injury and repair mechanisms. We assessed plasma levels of presumed neuron-derived EVs (NDEs), astrocyte-derived EVs (ADEs), and oligodendrocyte-derived EVs (ODEs) in 58 patients 5, 15, and 30 days post-ischemic stroke and 46 controls matched for cardiovascular risk factors using sandwich immunoassays. Subsets of brain-derived EVs were identified by co-expression of the general EV marker CD9 and markers for neurons (L1CAM, CD171), astrocytes (EAAT1), and oligodendrocytes (MOG) respectively.
View Article and Find Full Text PDFBackground: Although cancer patients' activities of daily living (ADL) are reported to decline before death, ADL trajectories have not been sufficiently clarified due to limitations in the assessment and analysis methods.
Objectives: To clarify the multiple trajectories of ADL in patients with terminal cancer using a comprehensive assessment measure.
Design: This was a retrospective observational study.