Intraoperative embolus formation during cardiopulmonary bypass affects the release of S100B.

Background: Intraoperative thromboembolism and the systemic inflammatory reaction are thought to play a role in causing cerebral dysfunction following cardiopulmonary bypass (CPB). Increased levels of S100B, an astroglial protein, have been linked to neuropsychological deficits after CPB. The present study investigated whether S100B release correlates with intraoperative embolus formation, thrombin formation, or the release of inflammatory parameters.

Influence of different autotransfusion devices on the quality of salvaged blood.

Background: Cardiopulmonary bypass causes a systemic inflammatory response and impaired hemostasis. We investigated whether intraoperative blood salvage with the cardiotomy suction contributes to these alterations. Furthermore, an alternative autotransfusion device (Haemonetics cell-saving device) was examined.

Reduced release of tissue factor by application of a centrifugal pump during cardiopulmonary bypass.

The application of a centrifugal pump might lead to a reduced release of tissue factor (TF) due to less blood cell damage. This could result in a decrease in activation of the extrinsic pathway of coagulation and embolus formation. In the present study, 60 patients undergoing coronary artery bypass grafting were randomly assigned to a centrifugal or a roller pump.

Response of the cellular immune system to cardiopulmonary bypass is independent of the applied pump type and of the use of heparin-coated surfaces.

Background: Cardiopulmonary bypass (CPB) is associated with an activation of leukocytes. The extent of this activation was thought to depend on the applied CPB-circuit set-up. The present study comparatively evaluated the effect of roller pump, centrifugal pump, and uncoated and heparin-coated surfaces.

A comparative evaluation of the effect of pump type and heparin-coated surfaces on platelets during cardiopulmonary bypass.

Cardiopulmonary bypass (CPB) is associated with hemostatic disorders, mainly due to platelet function defects. In the present prospective study, platelet count and GMP-140 expression on platelets were investigated to comparatively evaluate the impact of different CPB-circuit systems on platelets. The study included 61 patients undergoing coronary artery bypass grafting, randomly assigned to 3 groups.