Patient and physician exposure to X-rays at pediatric interventional cardiology - from world to Poland.

Ionizing radiation is considered as a harmful factor to health. However, X‑rays are widely used in diagnostic and therapeutic procedures such as those performed during cardiac interventions. Their use is particularly invaluable in saving life procedures when the risk of adverse effects of radiation is relatively low compared to the consequences of non-treated or treated with other invasive methods diseases.

Historical Perspective and Current Trends in Anticancer Drug Development.

Cancer is considered one of the leading causes of death in the 21st century. The intensive search for new anticancer drugs has been actively pursued by chemists and pharmacologists for decades, focusing either on the isolation of compounds with cytotoxic properties from plants or on screening thousands of synthetic molecules. Compounds that could potentially become candidates for new anticancer drugs must have the ability to inhibit proliferation and/or induce apoptosis in cancer cells without causing too much damage to normal cells.

Anticancer Properties of 3-Dietoxyphosphorylfuroquinoline-4,9-dione.

Herein, the antitumor activity of a novel synthetic analog with 5,8-quinolinedione scaffold, diethyl (2-(2-chlorophenyl)-4,9-dioxo-4,9-dihydrofuro [3,2-]quinolin-3-yl)phosphonate () was investigated on two breast cancer cell lines. This analog was selected from a small library of synthetic quinolinediones on the basis of its strong antiproliferative activity against MCF-7 and MDA-MB-231 cells and 4-5-fold lower cytotoxicity towards healthy MCF-10A cells. The morphology of MCF-7 and MDA-MB-231 cancer cells treated with changed drastically, while non-tumorigenic MCF-10A cells remained unaffected.

Ionizing radiation and volumetric mammographic density.

Objectives: Mammographic density (MD) refers to the percentage of dense tissue of an entire breast and was proposed to be used as a surrogate marker for breast cancer. High-dose ionizing radiation (IR) has been recognized as a breast cancer risk factor. The aim of our study was to investigate association between lifetime low dose ionizing radiation (LDIR) and MD.

Prognostic Significance of Expression in Lung Cancer Based on Bioinformatics Analysis.

High-mobility group protein 1 (HMGA1) participates in the processes of DNA transcription, replication, recombination, and repair. The gene is expressed abundantly during embryogenesis and is reactivated during carcinogenesis. gene expression has been associated with a high degree of malignancy, metastatic tendency, and poor survival in breast, colon, ovary, and pancreatic cancers.