Publications by authors named "M Mireles"

We report a method to directly 3-D print complex heterogeneous optical phantoms with programmable tissue-mimicking absorption and scattering properties. The proposed approach utilizes commercially available multi-color mixing extruders and off-the-shelf polylactic acid (PLA) filaments, making this technique low-cost and broadly accessible. We systematically characterized optical properties, including both absorption and reduced scattering coefficients, at a wide range of mixing ratios of gray, white and translucent filaments and validated our hypothesis of a linear-mixing model between the filament mixing ratios and the resulting optical properties.

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Article Synopsis
  • Researchers used broadband diffuse reflectance spectroscopy (DRS) and diffuse correlation spectroscopy (DCS) to assess deep tissue blood characteristics in a mouse model of clear cell renal cancer being treated with sunitinib.
  • The study involved 22 treated mice and 13 untreated controls, revealing significant reductions in total hemoglobin concentration, oxygen saturation, and blood flow index during treatment.
  • Findings indicated that early changes in blood flow and hemoglobin levels were linked to tumor characteristics, suggesting DRS/DCS can help predict how tumors might respond to antiangiogenic therapies.
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The low spatial resolution of diffuse optical tomography (DOT) has motivated the development of high-density DOT systems utilizing spatially-encoded illumination and detection strategies. Data compression methods, through the application of Fourier or Hadamard patterns, have been commonly explored for both illumination and detection but were largely limited to pre-determined patterns regardless of imaging targets. Here, we show that target-optimized detection patterns can yield significantly improved DOT reconstructions in both and experimental tests.

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Significance: Functional near-infrared spectroscopy (fNIRS) presents an opportunity to study human brains in everyday activities and environments. However, achieving robust measurements under such dynamic conditions remains a significant challenge.

Aim: The modular optical brain imaging (MOBI) system is designed to enhance optode-to-scalp coupling and provide a real-time probe three-dimensional (3D) shape estimation to improve the use of fNIRS in everyday conditions.

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High-energy laser facilities require high reflection multilayer coatings on meter-scale substrates. Due to stringent use specifications, a precise control of deposition parameters is necessary to tailor the optical and mechanical properties of components. The resulting coatings are sensitive to relative humidity variations, leading to a shift of their optical spectra called spectral shift.

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