Publications by authors named "M Milione"
Background: In resectable gastric/gastroesophageal junction adenocarcinoma, microsatellite instability-high (MSI-H) confers improved survival, but limited benefit from chemotherapy. Immunotherapy may eliminate the need for chemotherapy or surgery.
Patients And Methods: INFINITY is a multicenter, multicohort phase II trial (NCT04817826) investigating in cohort 1 the activity and safety of tremelimumab + durvalumab (T300/D) as neoadjuvant treatment of mismatch repair deficient/MSI-H, resectable gastric/gastroesophageal junction adenocarcinoma.
Article Synopsis
- MGMT silencing occurs in about 6-7% of pancreatic cancer (PAC) cases and is more common in tumors with non-ductal histology and KRAS wild type status.
- This silencing is linked to longer overall survival and is associated with fewer KRAS mutations, as well as immune exclusion features.
- The study suggests that MGMT-silenced PACs may respond better to treatments involving alkylating and DNA damaging agents, pointing to the potential for targeted therapy combinations.
Article Synopsis
- * The study tested the effects of three natural compounds—quercetin (QER), epigallocatechin gallate (EGG), and fisetin (FIS)—on patient-derived organoids (PDOs) obtained from polyps, assessing their impact on cell growth and apoptosis.
- * Fisetin (FIS) was the most effective compound in inducing cell death in the organoid models, suggesting that diets rich in these compounds could serve as a supplementary strategy to reduce CRC risk in FAP
Article Synopsis
- Colorectal cancer (CRC) is linked to factors like obesity and inflammation, which may disrupt immune response by accumulating foam cells (FC) in tumors, potentially impacting cancer progression.*
- The study involved analyzing tumor samples from CRC patients to investigate the relationship between FC and immune cell dynamics, highlighting the presence of reduced CD8 T cells and increased regulatory T cells in tumors with high FC accumulation.*
- Results indicated that higher levels of FC are associated with worse outcomes, including lower disease-free survival rates in CRC, and in vitro experiments showed that FC suppress CD8 T cell activity through mechanisms involving TGF-β.*
Objective: Digital pathology is an opportunity to revise the routine and old artisanal workflow, moving to standard operating procedures, quality control and reproducibility. Here the results of a survey promoted by the Coordinamento della Medicina di Laboratorio (CRC Med Lab) of the Lombardy region in Italy are reported to shed light on the current situation of digital adoption in the country.
Methods: The survey composed of 58 questions was sent to 60 pathology laboratories.