Publications by authors named "M Miklaszewska"
: Hemolytic uremic syndrome (HUS) is a known cause of acute kidney injury in children, but there are few recent reports on its epidemiology and outcome. We aimed to investigate trends in the incidence and the long-term outcomes of both Shiga toxin-producing -HUS (STEC-HUS) and atypical HUS (aHUS) in Poland over the last 12 years (2012-2023), based on the Polish Pediatric HUS and Pediatric Renal Replacement Therapy (RRT) Registries. : A total of 436 patients (301 with STEC-HUS and 135 with aHUS) were included.
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- IgA vasculitis (IgAV) is a pediatric disease characterized by skin and systemic symptoms, and researchers conducted comprehensive studies involving genome, transcriptome, and proteome analyses on a large cohort of IgAV patients and controls to better understand the disease mechanisms.* -
- Significant associations were found with specific genetic risk factors, including two novel non-HLA loci linked to IgA receptor functioning, which may contribute to disease development through altered immune responses.* -
- Systems biology approaches helped identify key regulatory networks and master regulators in myeloid cells, along with 21 genetic loci that overlap with IgA nephropathy, suggesting shared pathways in these related conditions.*
Background: We aimed to develop a tool for predicting HNF1B mutations in children with congenital abnormalities of the kidneys and urinary tract (CAKUT).
Methods: The clinical and laboratory data from 234 children and young adults with known HNF1B mutation status were collected and analyzed retrospectively. All subjects were randomly divided into a training (70%) and a validation set (30%).
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide. Decreased glomerular filtration rate is a known risk factor for disease progression. We aimed to examine factors that may contribute to disease progression in children that present with impaired eGFR at the onset of IgAN.
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- Lipid droplets (LDs) in seed tissues serve as storage for triacylglycerols (TAGs), crucial for providing energy and carbon for seedlings.
- The major degradation process for LDs involves lipolysis through lipases, but LDs can also be degraded via lipophagy—specifically microlipophagy in Arabidopsis seedlings.
- The study highlights interactions between structural LD proteins, like caleosins, and autophagy-related proteins (ATG8), suggesting a significant role of these proteins in LD degradation during seed germination.