Publications by authors named "M Mifune"
Article Synopsis
- A study examined the link between cognitive function and clinical aspects of chronic kidney disease (CKD) in Japanese patients without overt dementia.
- Out of 497 patients initially screened, 191 were analyzed, revealing average cognitive scores (MMSE) and correlations with age and kidney function, particularly noting that older patients (≥70 years) had lower scores.
- Findings suggest cognitive function is affected in CKD patients even without dementia, emphasizing the need for early interventions to safeguard cognitive and kidney health.
Article Synopsis
- The study investigated the link between urinary liver-type fatty acid-binding protein (L-FABP) levels and clinical characteristics of type 2 diabetes patients, particularly focusing on those with normal vs. elevated albumin levels.
- Urinary L-FABP was measured in 788 participants, revealing that high levels were significantly associated with factors like HbA1c, blood pressure, and renal function in normoalbuminuric patients, while specific medications and urinary albumin levels affected albuminuric patients.
- The findings suggest that elevated urinary L-FABP relates to metabolic issues such as high HbA1c and blood pressure, indicating it could be a valuable biomarker for assessing kidney health in diabetes patients.
Objective The effects of febuxostat therapy on hyperuricemia in patients with and without type 2 diabetes were compared in this retrospective observational study after pair-matching using the propensity scores. Methods In total, 160 patients with hyperuricemia were studied as the treated set, and the 155 subjects in whom the administration of febuxostat was not discontinued during the observation period were investigated in the full analysis. The study subjects were divided into two groups based on the style of initiation of febuxostat: initial and switching therapy from allopurinol administration.
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- - The study explored changes in clinical characteristics and medication prescriptions among type 2 diabetic patients experiencing severe hypoglycemia from 2008 to 2013, revealing significant shifts in medication types used.
- - An increase in patients using insulin, biguanides, and other newer medications was noted, while the use of sulfonylureas dropped significantly. Additionally, the frequency of medication errors contributing to hypoglycemia rose over the same period.
- - The findings highlight a rise in polypharmacy among insulin users and emphasize the need for effective education on medication management to prevent severe hypoglycemia in these patients.
Article Synopsis
- - The study aimed to explore how the duration of type 2 diabetes impacts the health status of elderly patients (aged 65 and older) compared to younger patients.
- - Results showed that longer diabetes duration was linked to higher insulin use and worse blood sugar control, with increased risks for conditions like diabetic retinopathy, nephropathy, and neuropathy in both age groups, but not for diseases like coronary heart disease in elderly patients.
- - The findings suggest that while diabetes duration affects microvascular complications, atherosclerotic diseases must be considered for effective management of elderly patients, regardless of how long they have had diabetes.