Publications by authors named "M Mieda"
Circadian rhythm mechanism in the suprachiasmatic nucleus and its relation to the olfactory system.
Front Neural Circuits
April 2024
Animals need sleep, and the suprachiasmatic nucleus, the center of the circadian rhythm, plays an important role in determining the timing of sleep. The main input to the suprachiasmatic nucleus is the retinohypothalamic tract, with additional inputs from the intergeniculate leaflet pathway, the serotonergic afferent from the raphe, and other hypothalamic regions. Within the suprachiasmatic nucleus, two of the major subtypes are vasoactive intestinal polypeptide (VIP)-positive neurons and arginine-vasopressin (AVP)-positive neurons.
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- - The study found that tumescenamide C effectively inhibits the growth of the scab-forming pathogen S. scabiei NBRC13768, with an impressive IC value of 1.5 μg/mL.
- - Researchers generated three resistant strains of S. scabiei, which showed changes in genes involved in transporting cellobiose and related substances, leading to decreased production of the harmful toxin thaxtomin A.
- - The antimicrobial activity of tumescenamide C appears to be linked to its interaction with the cell wall component wall teichoic acid (WTA), as changes in WTA levels were observed in the resistant strains, suggesting that tumescenamide C targets the bacterial cell wall for its effects
Objective: Imeglimin is a novel antidiabetic drug structurally related to metformin. Metformin has been shown to modulate the circadian clock in rat fibroblasts. Accordingly, in the present study, we aimed to determine whether imeglimin can impact the circadian oscillator in mouse embryonic fibroblasts (MEFs).
View Article and Find Full Text PDFProkineticin 2 (Prok2) is a small protein expressed in a subpopulation of neurons in the suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals. Prok2 has been implicated as a candidate output molecule from the SCN to control multiple circadian rhythms. Genetic manipulation specific to Prok2-producing neurons would be a powerful approach to understanding their function.
View Article and Find Full Text PDFThe thalamic reticular nucleus (TRN) is a thin sheet of GABAergic neurons surrounding the thalamus, and it regulates the activity of thalamic relay neurons. The TRN has been reported to be involved in sensory gating, attentional regulation, and some other functions. However, little is known about the contribution of the TRN to sequence learning.
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