Copper complexes with bioactive ligands. Part II--Antifungal activity.

Antifungal activity of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of the composition Cu(2-MeSNic)2(MeNia)(2).4H2O (where MeNia is N-methylnicotinamide), and Cu(2-MeSNic)2(Nia)(2).2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide, iNia, or ethyl nicotinate, EtNic) were tested on various strains of filamentous fungi by the macrodilution method.

Role of the H-2 complex in the homing affinity of injected lymphoid cells to the host's lymph nodes.

The role of H-2 and non-H-2 gene products was studied in a model of non-immune cell-cell interactions which underlie the homing affinity to lymph nodes of injected 51Cr-labelled lymph node cells. The effect of various donor-recipient combinations was tested by comparing the allogeneic/syngeneic ratio of radioactivity recovered from the lymph nodes. The homing affinity was reduced to about 50% when the donor-recipient incompatibility extended over the whole H-2 chromosome.

HLA antigens in three Siberian populations.

The distribution of HLA phenotypes, gene and haplotype frequencies was studied in three Mongoloid populations in Central Asia (Tofs, Tuvinians and Buryats). In comparison with Caucasian populations increased frequency of HLA-A9, BW40 and BW15 and haplotype A9, BW15 as well as low frequency of HLA-A1, B8 and B12 are characteristic of all three populations. Buryats seem to have the relatively highest admixture of Caucasoid genes.

Study of H-2 antigens of wild mice (Mus musculus L.).

226 wild mice originating from 16 different localities were tested serologically, using a battery of anti-H-2 sera. The results indicate the existence of a large number of hitherto unknown H-2 haplotypes. Three cogenic resistant strains (B10.

Cross-reactions between the major histocompatibility system of man and mice (HL-A and H-2). Cytotoxic action of anti-H-2 sera on lymphocytes.

Alloimmune congenic anti-H-2 sera, dependent on the combination of H-2 haplotypes of donor-recipient strains, exert a strong cytotoxic activity against human cells. While strong sera react with almost all samples of human cells, in serial dilutions pronounced differences in strength of reactions can be found with different human cell samples in correlation with their HL-A phenotype. The strongest associations of some anti-H-2f and anti-H-2p sera were found with HL-A2 (r = 0.