Publications by authors named "M Michaelis"
Purpose: Patients with Cushing's syndrome (CS) have an increased venous thromboembolism (VTE) risk with most studies focusing on the perioperative period. The purpose of this study was to assess the 5-year VTE risk and identify predictors of VTE at CS diagnosis.
Methods: A comparative nationwide retrospective cohort study of 609 patients (mean age 48.
The PI3K-AKT and MEK-ERK signaling pathways are integral to fundamental cellular processes such as proliferation, viability, and differentiation. In granulosa cells (GCs), these pathways are activated by FSH and IGF1 through respective receptors. We investigated the comparative transcriptome changes induced by AKT and ERK pathways using corresponding inhibitors in GCs.
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- EPs 7630 is a clinically proven plant extract that effectively treats various acute respiratory infections while reducing antibiotic use, which is crucial amid increasing antibiotic resistance.
- It works through multiple mechanisms, including antibacterial, antiviral, and immunomodulatory effects, allowing it to address respiratory infections at different stages of the disease.
- The findings suggest that plant extracts like EPs 7630 have significant potential as evidence-based treatments, warranting further research and testing like conventional medications.
Sortase-mediated ligation (SML) has become a powerful tool for site-specific protein modification. However, sortase A (SrtA) suffers from low catalytic efficiency and mediates an equilibrium reaction. Therefore, ligations with large macromolecules may be challenging.
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- - The poster illustrates how drug-resistant cancer cell lines are created for research purposes.
- - It highlights the significance of these cell lines in studying cancer treatment challenges.
- - The development of these cell lines aids in advancing our understanding of cancer biology and potential therapies.