Publications by authors named "M Mhlanga"
The Human Cell Atlas (HCA) is a global partnership "to create comprehensive reference maps of all human cells-the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring, and treating disease." ( https://www.humancellatlas.
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- Colorectal surgery often leads to significant postoperative complications, mainly infections, potentially due to monocyte epigenetic changes and immune tolerance.
- A study involving 100 patients measured changes in damage-associated molecular patterns (DAMPs) and cytokine production, alongside exploratory analyses of proteins and DNA accessibility in monocytes.
- Results showed significant increases in plasma DAMPs, particularly HMGB1 and mitochondrial DNA post-surgery, while in vitro tests revealed that HSP70 and HMGB1 reduced the cytokine production capacity of immune cells.
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- * A project aimed to address these issues by creating targeted peer support groups for pregnant adolescents and young mothers in Epworth district, using a 'Champions of Change' approach for comprehensive sexuality education.
- * Results showed significant improvements in knowledge, attitudes, and healthcare-seeking behaviors related to sexual and reproductive health, as well as enhanced service quality and provider friendliness.
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- Chronic high cholesterol levels lead to systemic immune responses that accelerate atherosclerosis, but the impact of alternating high-fat diets (HFD) had not been well studied.
- Researchers used a mouse model to compare the effects of an alternating HFD versus a continuous HFD on atherosclerosis progression, finding that the alternating diet significantly worsened the condition.
- The study revealed that this worsening was linked to IL-1β production, which triggered inflammatory responses and increased neutrophil levels that contributed to plaque formation and exacerbated atherosclerosis, suggesting that targeting these pathways could reverse the effects.
Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness to secondary stimuli. Although our understanding of the molecular regulation of trained immunity has increased, the role of adaptive immune cells herein remains largely unknown. Here, we show that T cells modulate trained immunity via cluster of differentiation 40-tissue necrosis factor receptor-associated factor 6 (CD40-TRAF6) signaling.
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