Oral ibuprofen versus placebo in closure of patent ductus arteriosus in preterm neonates, a randomized control trial.

Background: A consensus on treatment of patent ductus arteriosus (PDA) in preterm neonates remains elusive. Conservative management has recently gained popularity due to medical treatment lacking the evidence of benefit in terms of mortality and morbidity.

Objective: This study compares the efficacy of the standard dose of oral Ibuprofen versus placebo in the closure of PDA in preterm neonates ≤34 weeks gestation.

Purslane leaf powder dietary supplementation rescues cadmium-induced disruption of behavior, antioxidant status, and expression of tight junction genes, in the brain of Nile tilapia (Oreochromis niloticus).

This study examined the effects of supplementing the Nile tilapia (Oreochromis niloticus) diet with purslane (Portulaca oleracea L.) leaf powder (PLNP, 10 g/kg) on neurobehavioral performance, brain oxidative status, tight junction mRNA expression, and brain histology in fish exposed to waterborne cadmium (Cd, 50 μg /L) for 60 days. Adding PLNP to the diet ameliorated the Cd-induced decline in ingestive behavior and swimming behavior, and reversed the Cd-induced increase in aggressive behavior.

Exploring the CD3/CD56/TNF-α/Caspase3 pathway in pyrethroid-induced immune dysregulation: curcumin-loaded chitosan nanoparticle intervention.

Introduction: Conflict reports exist on the impact of pyrethroid insecticides on immune function and the probable underlying mechanisms.

Methods: This study evaluated the effect of an extensively used pyrethroid insecticide, fenpropathrin (FTN) (15 mg/kg b.wt), on the innate and humoral immune components, blood cells, splenic oxidative status, and mRNA expression of CD3, CD20, CD56, CD8, CD4, IL-6, TNF-α, and Caspase3 in a 60-day trial in rats.

Trends of biomolecule-conjugated nanoparticles as antibiofilm.

Biofilm is a powerful barrier that significantly enhances the pathogenicity of bacteria and the development of multidrug resistance. Nanoparticles (NPs) coupled with biomolecules provide a novel approach to addressing this issue. This review briefly discusses the current trends in Biomolecule-Conjugated NPs combined with enzymes, antibiotics, biosurfactants, and natural bioactive compounds as antibiofilm agents emphasizing their superior antibiofilm activity.

Pumpkin seeds oil rescues colchicine-induced neurotoxicity in rats via modifying oxidative stress, DNA damage, and immunoexpression of BDNF and GFAP.

Colchicine (CHC), a poisonous plant alkaloid, has been widely utilized for decades in the treatment of gout, but has a rather low therapeutic index, which causes oxidative stress leading to cognitive impairment, brain damage, apoptosis, and hitopathological alterations in humans and experimental animals. The present investigation evaluated the potential palliative effect of the pumpkin seeds oil (PSO) at a dose of 4 ml/kg b.wt against CHC (0.