Tableting technology from the individual and new galenic alkaloid consisting preparations of the Phellodendron lavallei bark.

The aim of the research was to work out the technology and tablet composition from new galenic preparations consisting of alkaloids of the bark of Phellodendron lavallei and hydrochloride of berberin on the base of complex research. The bark of the Phellodendron lavallei introduced in Georgia contains alkaloids, from which 2% is berberine used for curing chronicle hepatitis, hepatic cholecystitis and bilestone disease. The structural-mechanical and technological character of tablets and their masses were defined by the known methodic.

[Changes of metabolic indices caused by berberin and extract, obtained from the bark of Phellodendron lavalei, introduced in subtropic regions of Georgia, in streptozotocin induced diabetic rats].

The goal of the study was to identify changes in lipid metabolism, functional condition of liver and kidney influenced by berberin and extract, obtained from the bark of Рhеllodendron lavalei, introduced in sub tropic regions of Georgia, in streptozotocin induced diabetic rats. Diabetes in animals was induced by single intraperitoneal injection of streptozotocin in 1 M citrate buffer, pH 4.5, dose 40 mg/kg per body weight, 1 ml volume.

[Antidiabetic activity of berberin and extract, obtained from the bark of Phellodendron lavalei, introduced in subtropic regions of Georgia, in streptozotocin induced diabetic rats].

The goal of the study was to identify antidiabetic impact of berberin and extract, obtained from the bark of Рhеllodendron lavalei, introduced in subtropic regions of Georgia. The study was conducted on Streptozotocin induced diabetic rats. Diabetes in animals was induced by single intraperitoneal injection of streptozotocin in 1M citrate buffer, pH 4.

Anatomical and morphological description of Phellodendron lavallei Dode stem bark.

Phellodendron lavallei Dode (Rutaceae) is native to Japan. It was introduced in Georgia (Adjara) in 80th of XX century. In medicine the genus of Phellodendron Rupr.

[Activity of lysosomal enzymes in rabbit brain during the development of edema].

Liberation and consequent activation of lysosomal enzymes seems to play significant role in the development of brain edema. In the present experiment with adult rabbits, anesthetized with urethane we investigated in the brain tissue homogenates the activity of four lysosomal enzymes, such as desoxyribonuclease, ribonuclease, katepsine D and acid phosphatase following the development of osmotic brain edema as well as in control animals. The activities of the lysosomal enzymes were investigated with a spectrophotometric technique.