[MOTOR NEUROPATHY PRECEDING PRIMARY SYSTEMIC AMYLOIDOSIS].

Primary (AL) systemic amyloidosis is an uncommon disorder in which immunoglobulin light chains are deposited in the tissues as amyloid, resulting in organ dysfunction. The initial symptoms are frequent fatigue and weight loss, and common manifestations include nephrotic syndrome, cardiomyopathy, peripheral neuropathy or hepatomegaly. Histological examination reveals some degree of amyloid deposition in virtually every organ system except the central nervous system (CNS).

Impact of thermal lensing on the TMI threshold powers in rod-type Yb-doped fiber amplifiers.

The impact of thermal lensing (TL) on the transverse mode instability (TMI) threshold power in rod-type fiber amplifiers is investigated. Simulations are conducted with a 3D coupled mode analysis on a set of five scaled large pitch fiber (LPF) amplifiers. The LPF fibers are represented by surrogate step-index fibers (SIFs) with scaled cladding diameters, core diameters, and numerical apertures for a fixed normalized frequency V equal to 3.

Clinicoradiologic Criteria for the Diagnosis of Stroke-like Episodes in MELAS.

Background And Objectives: Stroke-like episodes (SLEs) in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome are often misdiagnosed as acute ischemic stroke (AIS). We aimed to determine unique clinical and neuroimaging features for SLEs and formulate diagnostic criteria.

Methods: We retrospectively identified patients with MELAS admitted for SLEs between January 2012 and December 2021.

Clinical score for early diagnosis and treatment of stroke-like episodes in MELAS syndrome.

Background And Objectives: Stroke-like episodes (SLEs) in patients with MELAS syndrome are often initially misdiagnosed as acute ischemic stroke (AIS), resulting in treatment delay. We aimed to determine clinical features that may distinguish SLEs from AISs and explore the benefit of early L-arginine treatment on patient outcomes.

Methods: We looked retrospectively for MELAS patients admitted between January 2005 and January 2022 and compared them to an AIS cohort with similar lesion topography.

Repeated lumbar puncture in search of oligoclonal bands - What is the yield?

Background: Cerebrospinal fluid (CSF) oligoclonal bands (OCBs) are immunoglobulins that represent intrathecal synthesis during central nervous system infection or inflammation. As repeated lumbar puncture (LP) is usually not performed unless clinically indicated, there is very limited data on the natural history and course of OCBs status in the CSF, its relation to disease activity, duration of persistence, and the rate of either CSF conversion of OCBs or disappearance.

Methods: We retrospectively collected data from adult patients with various neurological syndromes who had repeated CSF samplings.