Yersinia pestis requires the 2-component regulatory system OmpR-EnvZ to resist innate immunity during the early and late stages of plague.

Plague is transmitted by fleas or contaminated aerosols. To successfully produce disease, the causal agent (Yersinia pestis) must rapidly sense and respond to rapid variations in its environment. Here, we investigated the role of 2-component regulatory systems (2CSs) in plague because the latter are known to be key players in bacterial adaptation to environmental change.

New insights into how Yersinia pestis adapts to its mammalian host during bubonic plague.

Bubonic plague (a fatal, flea-transmitted disease) remains an international public health concern. Although our understanding of the pathogenesis of bubonic plague has improved significantly over the last few decades, researchers have still not been able to define the complete set of Y. pestis genes needed for disease or to characterize the mechanisms that enable infection.

Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response.

Background: Yersinia pestis (the plague bacillus) and its ancestor, Yersinia pseudotuberculosis (which causes self-limited bowel disease), encode putative homologues of the periplasmic lysozyme inhibitor Ivy and the membrane-bound lysozyme inhibitor MliC. The involvement of both inhibitors in virulence remains subject to debate.

Methods: Mutants lacking ivy and/or mliC were generated.

[Clinical epidemiological study of acute gastro-enteritis outbreak recorded in a children community, in Iaşi, May, 2009].

Unlabelled: Acute diarrheal disease affect all demographic structures and it is considered a major cause of morbidity and mortality for young age groups; underreporting is due to clinical and epidemiological diversity, everywhere, including the developed countries.

Material And Methods: The authors present an epidemic outbreak of acute gastroenteritis by rotavirus in a community of 240 children. Processing and interpretation of collected data was done by statistical, mathematical and computerized methods.

[Assessment of visual function under treatment with topical antiglaucoma agents and systemic vasodilators. Clinical study on glaucoma patients].

Unlabelled: The authors present some observations regarding the use of topical anti-glaucoma therapy and systemic vasodilators.

Material And Methods: The study was carried out on a series of 996 glaucoma patients, of which 54.1% with primary open-angle glaucoma, 5.