Publications by authors named "M Mercedes Binda"
Objectives: Anticentromere antibodies (ACA) are typically found in limited cutaneous systemic sclerosis (lcSSc), whereas patients with anti-topoisomerase I antibodies (ATA) usually exhibit diffuse cutaneous involvement (dcSSc). We aimed to investigate the clinical phenotype and outcome of ACA-dcSSc.
Methods: A systematic literature review was conducted (January 1970 to April 2023) across MEDLINE, Scopus and OVID, to define whether SSc patients (population) within the ACA-dcSSc subset (exposure) had higher/lower risk for major organ involvement (interstitial lung disease-ILD, pulmonary hypertension-PH, primary myocardial involvement-PMI, scleroderma renal crisis-SRC) and mortality (outcomes) compared to ACA-lcSSc and ATA-dcSSc.
Article Synopsis
- HE4 is a protein that helps promote fibrosis by preventing collagen breakdown; this study aimed to evaluate HE4 as a biomarker for interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathies (IIMs).
- Researchers enrolled 90 IIMs patients and 42 healthy controls, finding that serum HE4 levels were significantly higher in patients with IIMs, particularly in those diagnosed with ILD.
- The study concluded that HE4 levels could serve as a useful biomarker for detecting and assessing ILD in IIMs patients, although there was no significant link between baseline HE4 and progressive fibrosing ILD in follow-up cases.
In complex systems, the system's self-regulation processes can transition between states of equilibrium and disequilibrium, leading to changes in the distribution of players within the playing space. Actions that are surprising, rare, or out of the ordinary tend to be valued for their potential to destabilize the opposing defensive structure, altering player dispersion, and creating fragile spaces for the attack. With advancements in understanding the influence of the environment on players' affordances, the tactical consequences from individuals' solutions to various scenarios and their impact on the game context becomes a rich area for investigation.
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- Uterine ichthyosis is a rare condition where the endometrial surface is replaced by keratinized squamous epithelium, which can pose risks of premalignant or malignant lesions.
- A case study of a 66-year-old patient revealed high-grade dysplasia in the metaplastic squamous epithelium, highlighting the need for careful evaluation and potential surgical intervention.
- The rarity of this condition calls for more research to create clear diagnostic and treatment guidelines, stressing the importance of clinical vigilance and teamwork in patient management.
Systemic sclerosis sine scleroderma is more aggressive in children than in adults.
Rheumatology (Oxford)
September 2024
Objectives: To compare the clinical and laboratory features of paediatric SSc sine scleroderma (ssJSSc) with adult-onset ssSSc.
Methods: Demographic, clinical and laboratory data of ssJSSc, retrospectively retrieved from our hospital medical records, case reports from the literature and from the Pediatric Rheumatology European Society JSSc registry, were compared with the Padua cohort of adult patients with ssSSc. Patients were defined as having ssSSc if they never had skin involvement but all the following features: (i) RP and/or digital vasculopathy, (ii) positive ANA, (iii) internal organs involvement typical of scleroderma and (iv) no other defined CTD.