Publications by authors named "M Mennuni"
Impact of a personalized, strike early and strong lipid-lowering approach on LDL-cholesterol levels and cardiovascular outcome in patients with acute myocardial infarction.
Eur Heart J Cardiovasc Pharmacother
January 2025
Aims: Considering the lack of evidence, we evaluated the impact on cardiovascular outcome of the systematic introduction in our institution of a personalized strike early and strong (SES) approach for lipid-lowering therapy (LLT) in patients admitted for acute myocardial infarction (MI).
Methods And Results: We retrospectively analyzed data from 500 consecutive patients hospitalized across three periods: Period A (N=198, January-June 2019), when the LDL-C goal was <70 mg/dL and a stepwise LLT approach was recommended; Period B (N=180, January-June 2021), when the LDL-C goal was <55 mg/dL and a stepwise approach was recommended; Period C (N=122, January-June 2023), when the LDL-C goal was <55 mg/dL and our SES protocol was implemented. Primary endpoints were achievement of the LDL-C goal during follow-up and one-year incidence of major adverse cardiovascular events (MACE).
Pulmonary embolism (PE) is a life-threatening medical condition caused by the thrombotic occlusion of one or more branches of the lung vasculature, which represents the third most common cause of cardiovascular mortality after myocardial infarction and stroke. PE treatment requires a tailored approach based on accurate risk stratification and personalized treatment decision-making. Anticoagulation is the cornerstone of PE management, yet patients at higher clinical risk may require more rapid reperfusion therapies.
View Article and Find Full Text PDFArticle Synopsis
- Pulmonary embolism (PE) after childbirth poses serious risks to both mothers and infants, requiring careful management.
- The case report highlights a patient with intermediate-high risk PE who experienced hemodynamic instability, complicating treatment.
- This situation emphasizes the need for updated clinical practices to effectively handle PE in post-partum patients.
Article Synopsis
- Lung adenocarcinoma is a serious cancer that is a major cause of death globally, and this study examines how mitochondrial DNA (mtDNA) copy number impacts tumor growth in mice.
- Increased mtDNA levels were found in lung tumors caused by KRAS expression, leading to larger tumors in mice with higher mtDNA and reduced growth when mtDNA was depleted.
- The findings suggest mtDNA copy number is critical for lung cancer progression and could pave the way for new cancer treatments, while immune responses in the lung remained unaffected by mtDNA levels.
Background: Several repair strategies emerged as possible treatment for severe mitral regurgitation (MR). A systematic review and meta-analysis was performed to compare the different percutaneous mitral valve repair approaches.
Methods: PubMed and Scopus electronic databases were scanned for eligible studies until December 11th, 2023.