Gut microbiota changes are associated with abnormal metabolism activity in children and adolescents with obsessive-compulsive disorder.

Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disorder characterized by recurrent intrusive thoughts or repetitive behaviors. We sought to better understand the structure of gut microbiota in first visit registration, treatment-naive children and adolescents with OCD, and the relationship between gut microbiota and fecal metabolites. Thus we studied the gut microbial population using 16 S rRNA sequencing in 49 children (8-17 years of age) with OCD, 42 healthy controls (HCs).

Unraveling the neural dichotomy of consensus and idiosyncratic experiences in short video viewing.

Human experiences are inherently shaped by individual perspectives, leading to diverse interpretations of the same events. However, shared activities, such as communal film watching or sports viewing, underscore the dual nature of these experiences: collective joy arises through social interactions, while individual emotional responses are influenced by personal preferences. The neural mechanisms underlying this interplay between shared and idiosyncratic experiences, particularly in the context of reward processing, remain insufficiently explored.

E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat.

Thermogenic fat, including brown and beige fat, dissipates heat via thermogenesis and enhances energy expenditure. Thus, its activation represents a therapeutic strategy to combat obesity. Here, we demonstrate that levels of F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin protein ligase, negatively correlate with thermogenic fat functionality.

Distributed aggregative optimization with affine coupling constraints.

This paper investigates a distributed aggregative optimization problem subject to coupling affine inequality constraints, in which local objective functions depend not only on their own decision variables but also on an aggregation of all the agents' variables. The formulated problem encompasses numerous practical applications, such as commodity distribution, electric vehicle charging, and energy consumption control in power grids. Hence, there is a compelling need to explore a new neurodynamic approach to address this.

Side-Chain and Ring-Size Effects on Permeability in Artificial Water Channels.

Artificial water channels (AWCs) have emerged as a promising framework for stable water permeation, with water transport rates comparable to aquaporins (3.4-40.3 × 10 HO/channel/s).