Publications by authors named "M Melpignano"
Article Synopsis
- The study investigates the role of mesenteric lymph node (MLN) involvement in the prognosis of advanced ovarian cancer (AOC) patients who underwent surgeries from 2007 to 2017.
- Out of 83 patients analyzed, 51.8% had positive MLN involvement, which correlated significantly with involvement in pelvic and aortic lymph nodes and deeper bowel infiltration.
- The findings suggest that negative MLN status is associated with better overall and disease-free survival, highlighting the importance of radical bowel resection during surgery for AOC with bowel involvement.
Article Synopsis
- The study aimed to investigate the outcomes of pelvic lymphadenectomy in early-stage endometrial cancer, focusing on how age and body mass index affect survival rates.
- Analyses showed that patients over 65 years have significantly lower cancer-specific survival (CSS) and overall survival (OS) rates compared to younger patients, regardless of lymphadenectomy status.
- The results indicate that older age, higher tumor grade, and higher stage are linked to worse prognoses, and obesity also contributes negatively to outcomes in older patients.
Article Synopsis
- A phase 2 study evaluated the safety and efficacy of neoadjuvant chemotherapy using irinotecan and cisplatin in patients with locally advanced cervical cancer at 13 centers in Italy from 2000 to 2003.
- Out of 71 patients analyzed, the overall response rate was 73.2%, with 12.7% achieving complete responses and 60.6% showing partial responses.
- Despite some serious adverse events, the treatment showed a promising overall survival rate of 87% at 4 years, suggesting potential for further investigation in a phase 3 study.
Background: Median laparotomy is the most common approach to the abdominopelvic cavity in patients with gynaecological tumours.
Aims: The primary endpoint of the study was to evaluate the onset of incisional hernia. The secondary endpoint was to evaluate the onset of infection, wound dehiscence, wound infection, and scar pain during the post-operative period.
A case of primary adenocarcinoma of the rectovaginal septum (PARVS) is reported with clinical and pathological findings. A 37-year-old Caucasian woman with a history of sterility and small posterior leiomyoma, a few months after a cesarean section, was admitted because of vaginal spotting, abdominal pain and constipation. Her previous history did not reveal exposure to diethylstil bestrol (DES).
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