Synthesis, Biological Activity, and Molecular-Docking Studies of New Brassinosteroid Analogs.

Much work has been dedicated to the quest to determine the structure-activity relationship in synthetic brassinosteroid (BR) analogs. Recently, it has been reported that analogs with phenyl or benzoate groups in the alkyl chain present activities comparable to those shown by natural BRs, depending on the nature of the substituent in the aromatic ring. However, as it is well known that the activity depends on the structure of the whole molecule, in this work, we have synthesized a series of compounds with the same substituted benzoate in the alkyl chain and a hydroxyl group at C3.

Schistosomiasis in migrant children and adolescents in a paediatric tropical referral unit in Spain: diagnosis and long-term management challenges.

Globalisation and population movement have led to an increasing number of migrant children residing in areas non-endemic for schistosomiasis. However, diagnosing and managing schistosomiasis in children remain controversial. This study aims to investigate the prevalence of schistosomiasis in migrant children and to describe the diagnostic approach and management strategies, including long-term follow-up, to explore the potential role of serological tests in evaluating treatment response.

Unmasking seasonal cycles in a high-input dairy herd in a hot environment: How climate shapes dynamics of milk yield, reproduction, and productive status.

This study aimed to predict the annual herd milk yield, lactation, and reproductive cycle stages in a high-input dairy herd in a zone with prolonged thermal stress. Also, the impact of climatic conditions on milk yield and productive and reproductive status was assessed. An autoregressive integrated moving average (ARIMA) model was used in data fitting to predict future monthly herd milk yield and reproductive status using data from 2014 to 2020.